Tamoxifen EP Impurity F HCl CAS 15917-65-4
| CAS No. | 15917-65-4 |
| Molecular Formula | C25H27NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tamoxifen EP Impurity F HCl.
CATO supplies Tamoxifen EP Impurity F HCl (CAS 15917-65-4), a pharmacopoeial impurity reference standard (molecular formula C25H27NOHCl, MW 393.95 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tamoxifen EP Impurity F HCl (C25H27NOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 393.95 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tamoxifen EP Impurity F HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H27NO HCl |
| Molecular Weight | 393.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tamoxifen Standards
- Tamoxifen (CAS 10540-29-1)
- Tamoxifen Citrate Impurity 25 (CAS 114828-90-9)
- Tamoxifen Impurity 18 (CAS 123091-15-6)
- Tamoxifen EP Impurity A (CAS 13002-65-8)
- Tamoxifen Dimer (CAS 1346606-51-6)
- Tamoxifen Impurity 15 (CAS 157698-32-3)
- Tamoxifen Citrate EP Impurity D Hydrochloride(E-Isomer) (CAS 15917-51-8)
- Tamoxifen Citrate - Impurity D (CAS 197251-11-9)
Recommended Standards
- Roflumilast Impurity 13 (CAS 53173-70-9)
- Fludarabine Phosphate EP Impurity J (CAS CATO-C4X-184610)
- Dotinurad Impurity 10 (CAS 1285573-42-3)
- 2-[4-(benzyloxy)phenyl]-2-methoxyacetic acid (CAS 701263-32-3)
- Imidazo[2,1-b]thiazole-6-carbaldehyde (CAS 120107-61-1)
- ((3-Methoxypropyl)azanediyl)bis(ethane-2,1-diyl) bis(2-methylacrylate) (CAS 93962-71-1)
- Clindamycin Impurity 164 (CAS 1123211-65-3 (free base))
- 1-(Azetidin-3-yl)-5-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (CAS 1395071-06-3)
- 4-(Dimethylamino)-3-hydroxybenzonitrile (CAS 1243476-88-1)
- Tirzepatide Impurity 9 (CAS CATO-C4X-32409)
Why CATO?
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