Sitagliptin Impurity 161 CAS 1608491-98-0
| CAS No. | 1608491-98-0 |
| Molecular Formula | C22H24F6N4O2 |
| Molecular Weight | 490.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Sitagliptin Impurity 161 (CAS 1608491-98-0), a pharmacopoeial impurity reference standard (molecular formula C22H24F6N4O2, MW 490.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C22H24F6N4O2, Sitagliptin Impurity 161 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 490.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H24F6N4O2 |
| Molecular Weight | 490.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 104 (CAS CATO-C4X-1144104)
- Sitagliptin Impurity 128 (CAS CATO-C4X-1144128)
- Sitagliptin-N-sulfate (CAS 940002-57-3)
- Sitagliptin Impurity 25 (CAS CATO-C4X-114425)
- Sitagliptin impurity 143 (CAS CATO-C4X-1144143)
- Sitagliptin impurity 146 (CAS CATO-C4X-1144146)
- Sitagliptin Impurity 87 (CAS CATO-C4X-114487)
- Sitagliptin Impurity 149 (CAS CATO-C4X-1144149)
Recommended Standards
- N-(4-(4-Bromophenyl)thiazol-2-yl)-2-(methylthio)-N-((tetrahydrofuran-2-yl)methyl)nicotinamide (CAS 950064-08-1)
- (R)-4-((S)-1-Fluoroethyl)-3-(2-(((S)-1-(4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one (CAS 1628805-46-8)
- 3-((2-Chloro-6-fluorobenzyl)thio)-5-(((4-chlorobenzyl)thio)methyl)-4-phenyl-4H-1,2,4-triazole (CAS 344269-58-5)
- (2R,3S)-2-(2,2-Bis(4-fluorophenyl)benzo[d][1,3]dioxol-5-yl)chromane-3,5,7-triol (CAS 89329-09-9)
- Esmolol Impurity 21 (CAS CATO-C4X-189121)
- Naltrexone Impurity 62 (CAS CATO-C4X-147562)
- Pirfenidone Impurity 48 (CAS CATO-C4X-222948)
- 1-Phenyl-3,4-dihydroisoquinoline-7-carbaldehyde (CAS 823236-18-6)
- 1,2-Dihydronaphthalene (CAS 447-53-0)
- 2-((4-(Thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl)oxy)ethan-1-amine (CAS 1160246-48-9)
- Ethyl 1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazole-4-carboxylate (CAS 1312137-66-8)
- 1-Cyclopropyl-3,5-dimethoxybenzene (CAS 1063960-56-4)
- 2,4-Dichloro-N-methylbenzenesulfonamide (CAS 565181-75-1)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com