Sitagliptin impurity 146 CAS CATO-C4X-1144146
| CAS No. | CATO-C4X-1144146 |
| Molecular Formula | C18H19F6N7O2 |
| Molecular Weight | 479.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Sitagliptin impurity 146 (CAS CATO-C4X-1144146), a pharmacopoeial impurity reference standard (molecular formula C18H19F6N7O2, MW 479.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H19F6N7O2, Sitagliptin impurity 146 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 479.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19F6N7O2 |
| Molecular Weight | 479.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Sitagliptin Standards
- Sitagliptin impurity 143 (CAS CATO-C4X-1144143)
- Sitagliptin Impurity 25 (CAS CATO-C4X-114425)
- Sitagliptin-N-sulfate (CAS 940002-57-3)
- Sitagliptin Impurity 128 (CAS CATO-C4X-1144128)
- Sitagliptin Impurity 104 (CAS CATO-C4X-1144104)
- Sitagliptin Impurity 161 (CAS 1608491-98-0)
- Sitagliptin Impurity 129 (CAS CATO-C4X-1144129)
- Sitagliptin Impurity 87 (CAS CATO-C4X-114487)
Recommended Standards
- 2-[N-(2,4-Dichloro-5-methoxyphenyl)4-methylbenzenesulfonamido]-N-phenylacetamide (CAS 338961-23-2)
- 1-O-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)-β-D-glucopyranuronic Acid 2,3,4-Triacetate Methyl Ester (CAS 319926-19-7)
- (2-(7,7-Dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methyl acetate (CAS 1899834-77-5)
- 2-((5-(2-Bromophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide (CAS 332388-21-3)
- Amorolfine Impurity 39 (CAS CATO-C4X-154239)
- Paliperidone Impurity 28 (CAS 55665-95-7)
- Ertapenem Impurity 33 (CAS 1199797-43-7&402955-37-7 (mixture))
- 1,4-Bis(bromomethyl)benzene (CAS 623-24-5)
- Ethyl 2-(p-tolyl)acrylate (CAS 128839-68-9)
- Benzofuran-7-boronic acid pinacol ester (CAS 1192755-14-8)
- 2-Amino-N-(2-fluorophenyl)-3-(4-nitrobenzoyl)indolizine-1-carboxamide (CAS 904267-35-2)
- 1-(4-Aminopiperidin-1-yl)-2-methylpropan-1-one hydrochloride (CAS 1158391-26-4)
- 2-Methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid (CAS 1557851-24-7)
- Akt/SKG Substrate Peptide (CAS 276680-69-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com