Sitagliptin Impurity 25 CAS CATO-C4X-114425
| CAS No. | CATO-C4X-114425 |
| Molecular Formula | C16H16F6N5O4P |
| Molecular Weight | 487.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Sitagliptin Impurity 25 (CAS CATO-C4X-114425), a pharmacopoeial impurity reference standard (molecular formula C16H16F6N5O4P, MW 487.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C16H16F6N5O4P, Sitagliptin Impurity 25 contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 487.29 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16F6N5O4P |
| Molecular Weight | 487.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin-N-sulfate (CAS 940002-57-3)
- Sitagliptin Impurity 128 (CAS CATO-C4X-1144128)
- Sitagliptin Impurity 104 (CAS CATO-C4X-1144104)
- Sitagliptin Impurity 161 (CAS 1608491-98-0)
- Sitagliptin impurity 143 (CAS CATO-C4X-1144143)
- Sitagliptin impurity 146 (CAS CATO-C4X-1144146)
- Sitagliptin Impurity 87 (CAS CATO-C4X-114487)
- Sitagliptin Impurity 149 (CAS CATO-C4X-1144149)
Recommended Standards
- 5-(Dimethylamino)pyrimidine-2,4(1H,3H)-dione (CAS 37454-51-6)
- 2＇,7＇-Dichlorodihydrofluorescein Diacetate (CAS 4091-99-0)
- N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-2-(((4-chlorophenyl)sulfonamido)oxy)acetamide (CAS 306977-19-5)
- (4-(4-Iodophenyl)-1,1-dioxido-4H-benzo[b][1,4]thiazin-2-yl)(phenyl)methanone (CAS 1114886-20-2)
- Esmolol Impurity 75 (CAS CATO-C4X-189175)
- Fezolinetant Impurity 26 (CAS CATO-C4X-327026)
- Clindamycin Impurity 70 (CAS CATO-C4X-134170)
- Diclofenac sodium Impurity 7 (CAS 127792-34-1)
- 6-Bromo-2-chloro-3-methylphenol (CAS 1226808-67-8)
- 1-Methyl-3-[6-(methylthio)hexyl]imidazolium p-Toluenesulfonate (CAS 1352947-63-7)
- 1,1-bis(4-chlorophenyl)-2-{[(3-chlorophenyl)methyl]amino}ethan-1-ol 1J-327S 321432-85-3 (CAS 321432-85-3)
- N-(Benzo[d]thiazol-6-yl)-3-chloropropanamide (CAS 916791-24-7)
- 5-Methyl-2-pivalamidonicotinic acid (CAS 1203499-02-8)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
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