Articaine impurity 17 HCl CAS 161449-05-4
| CAS No. | 161449-05-4 |
| Molecular Formula | C14H22N2O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Articaine impurity 17 HCl (CAS 161449-05-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2O3SHCl and a molecular weight of 334.86 g/mol.
The molecular framework of Articaine impurity 17 HCl (C14H22N2O3SHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H22N2O3S HCl |
| Molecular Weight | 334.86 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Articaine Standards
- Articaine EP Impurity B (CAS 114176-52-2)
- Articaine EP Impurity B HCl (CAS 114176-52-2(Free Base))
- Articaine EP Impurity J (CAS 1160919-46-9)
- Articaine Impurity N21 (CAS 13781-65-2)
- Articaine impurity 01 (CAS 161448-93-7)
- Articaine EP Impurity A (CAS 1712677-79-6)
- Articaine EP Impurity A HCl (CAS 1712677-79-6(free base))
- Articaine EP Impurity E (CAS 1796888-45-3)
Recommended Standards
- Ciclosporin EP Impurity D (CAS 108027-45-8)
- Ticagrelor Impurity 137 (CAS 504-17-6)
- Drotaverin Impurity N1 (CAS 56046-20-9)
- 6-Morpholinopyridine-2-carboxylic Acid (CAS 554405-17-3)
- Abrocitinib Impurity 2 (CAS CATO-C4X-28842)
- N-(1-(4-fluorophenyl)ethyl)furan-2-carboxamide (CAS 923692-44-8)
- 2-(2-Methyl-4-oxoquinolin-1(4H)-yl)acetic acid (CAS 946666-39-3)
- 1-(3-Hydroxy-2-methylquinolin-4-yl)ethanone (CAS 1345515-22-1)
- Mirogabalin impurity 76 (CAS CATO-C4X-292476)
- Neuropeptide Y (1-24) amide (human, rat) (CAS 131448-51-6)
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