Tofacitinib Impurity N33 CAS 1615709-90-4
| CAS No. | 1615709-90-4 |
| Molecular Formula | C14H17N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 248.75 g/mol gives Tofacitinib Impurity N33 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Tofacitinib Impurity N33 (CAS 1615709-90-4), a pharmacopoeial impurity reference standard (molecular formula C14H17N2Cl, MW 248.75 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tofacitinib Impurity N33 (C14H17N2Cl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity N33 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H17N2 Cl |
| Molecular Weight | 248.75 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Mivacurium chloride Impurity 71 (CAS CATO-C4X-137571)
- Pramipexole EP Impurity B (CAS 1246815-83-7)
- Roxithromycin EP Impurity F (CAS 118267-18-8)
- 5-Trifluoromethyl-2H-pyridazine-2-one (CAS 244268-34-6)
- 898787-27-4 4-(5,5-Dimethyl-1,3-dioxan-2-yl)-1-(4-pentylphenyl)butan-1-one DTXSID30645983 (CAS 898787-27-4)
- 2-Chloro-4-methoxy-N,N-dimethylaniline (CAS 1369860-55-8)
- 2-Methyl-2-(4,4,4-trifluorobutyl)pyrrolidine hydrochloride (CAS 2126161-61-1)
- 4-(3-fluorophenyl)-3-methyl-1H-pyrazol-5-amine (CAS 1229025-29-9)
- 8-Bromo-3-chloropyrido[2,3-b]pyrazine (CAS 2306263-48-7)
- Des-[Ser]8-Liraglutide (CAS CATO-C4X-199233)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com