Chlorthalidone EP Impurity G CAS 16289-13-7
| CAS No. | 16289-13-7 |
| Molecular Formula | C14H9Cl2NO2 |
| Molecular Weight | 294.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Chlorthalidone EP Impurity G.
As a process- or degradation-related impurity, Chlorthalidone EP Impurity G (CAS 16289-13-7, C14H9Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Chlorthalidone EP Impurity G (C14H9Cl2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 294.13 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Chlorthalidone EP Impurity G under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl2NO2 |
| Molecular Weight | 294.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorthalidone Standards
- Chlorthalidone RC 3 (CAS 61959-32-8)
- Chlorthalidone RC 4 (CAS 55275-44-0)
- Chlorthalidone impurity 18 (CAS 87177-16-0)
- Chlorthalidone Impuruty 8 (CAS 82875-49-8)
- Chlorthalidone Impurity N1 (CAS 5543-24-8)
- Chlorthalidone Impurity 15 (CAS 956-92-3)
- Chlorthalidone impurity 16 (CAS CATO-C4X-158516)
- Chlorthalidone Impurity 7 (CAS 345930-31-6)
Recommended Standards
- Fosfomycin Impurity 58 (CAS CATO-C4X-131658)
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- Lorazepam Impurity 11 (CAS CATO-C4X-104111)
- tert-Butyl ((3S,5S)-5-(bromomethyl)-2-oxotetrahydrofuran-3-yl)carbamate (CAS 104241-30-7)
- Linezolid Impurity 20 (CAS CATO-C4X-107320)
- Etoposide Impurity 29 (CAS CATO-C4X-202429)
- Ceritinib Impurity 36 (CAS CATO-C4X-104836)
- 3-Pyridin-4-ylmethyl-1H-indole (CAS 5275-07-0)
- 2-Ethoxy-4-phenylpyrimidine-5-carbonitrile (CAS 89079-67-4)
- (E)-5-Fluoropent-2-ene-1,4-diamine (CAS 82006-58-4)
- 2-[(4-Aminobutyl)amino]pyridine-3-carboxylic acid (CAS 904813-60-1)
- 2,4-Difluoro-3-(trifluoromethoxy)benzoic acid (CAS 1119454-13-5)
- Nafamostat impurity 102 (CAS CATO-C4X-1332102)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com