Chlorthalidone Impurity N1 CAS 5543-24-8
| CAS No. | 5543-24-8 |
| Molecular Formula | C14H9ClO3 |
| Molecular Weight | 260.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Chlorthalidone Impurity N1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Chlorthalidone Impurity N1 (CAS 5543-24-8, C14H9ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C14H9ClO3, Chlorthalidone Impurity N1 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 260.67 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H9ClO3 |
| Molecular Weight | 260.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Chlorthalidone Standards
- Chlorthalidone Impurity 15 (CAS 956-92-3)
- Chlorthalidone RC 4 (CAS 55275-44-0)
- Chlorthalidone EP Impurity G (CAS 16289-13-7)
- Chlorthalidone RC 3 (CAS 61959-32-8)
- Chlorthalidone impurity 18 (CAS 87177-16-0)
- Chlorthalidone Impuruty 8 (CAS 82875-49-8)
- Chlorthalidone impurity 16 (CAS CATO-C4X-158516)
- Chlorthalidone Impurity 7 (CAS 345930-31-6)
Recommended Standards
- 4-Formylphenyl 2-chlorobenzoate (CAS 321726-55-0)
- Zidovudine EP Impurity B (CAS 25526-94-7)
- 3-Formylphenyl 4-chlorobenzoate (CAS 431998-21-9)
- Roxadustat Impurity 161 (CAS CATO-C4X-2213161)
- Posaconazole Impurity 58 (CAS CATO-C4X-120858)
- Regorafenib Impurity 22 (CAS CATO-C4X-104722)
- Rocuronium impurity 68 (CAS CATO-C4X-124268)
- 4-((2-Aminoethyl)amino)butan-1-ol (CAS 137020-06-5)
- 1-{[2-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbonyl}piperidine (CAS 1094568-38-3)
- 4-(3-Chloro-5,6-dihydrocyclopenta[c]pyrazol-2(4H)-yl)benzonitrile (CAS 63419-40-9)
- 3-(Furan-2-yl)-2-methyl-3-oxopropanal (CAS 1250242-78-4)
- Topiroxostat impurity 77 (CAS 103275-78-1)
- 4-Amino-5-benzoyl-2-(ethylthio)thiophene-3-carbonitrile (CAS 116170-97-9)
- Des-Ile17-Tirzepatide (CAS CATO-CPTD788956)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com