Empagliflozin impurity 231 CAS 1637561-86-4
| CAS No. | 1637561-86-4 |
| Molecular Formula | C17H14BrClO3 |
| Molecular Weight | 381.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Empagliflozin impurity 231 (CAS 1637561-86-4) is a certified pharmaceutical impurity reference standard with the molecular formula C17H14BrClO3 and a molecular weight of 381.65 g/mol.
Empagliflozin impurity 231 (C17H14BrClO3) contains a steroid core, a hydroxyl group, an ether linkage, chlorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Empagliflozin impurity 231 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H14BrClO3 |
| Molecular Weight | 381.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl/Br-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 104 (CAS 915095-84-0)
- Empagliflozin impurity 182 (CAS 915095-83-9)
- Empagliflozin impurity 226 (CAS CATO-C4X-1065226)
- Empagliflozin impurity 259 (CAS CATO-C4X-1065259)
- Empagliflozin Impurity 276 (CAS CATO-C4X-1065276)
- Empagliflozin Impurity 277 (CAS CATO-C4X-1065277)
- Empagliflozin Impurity 279 (CAS CATO-C4X-1065279)
- Empagliflozin impurity 194 (CAS CATO-C4X-1065194)
Recommended Standards
- Ethyl 2-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazinyl)-3,3,3-trifluoro-2-hydroxypropanoate (CAS 400074-12-6)
- ((2R,3S,4R,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 21466-01-3)
- 284686-20-0 N-[5-Bromo-2-(cyclopropylamino)-4-methyl-3-pyridinyl]-2-chloro-3-pyridinecarboxamide (CAS 284686-20-0)
- 2-(2-Bromophenyl)-5-((4-chlorobenzyl)thio)-1,3,4-oxadiazole (CAS 500210-57-1)
- Clopidogrel Impurity 63 (CAS CATO-C4X-102963)
- N-Nitroso Tofacitinib Impurity 185 (CAS CATO-C4X-1079185)
- Rebamipide Impurity 53 (CAS CATO-C4X-152353)
- N-(Azido-PEG3)-N-Boc-PEG3-NHS ester (CAS 2112731-51-6)
- Ethyl 2-{[6-chloro-2-(4-chlorophenyl)-1H-1,3-benzimidazol-1-yl]oxy}propanoate (CAS 338978-88-4)
- 6-Amino-2-thioxo-1,2-dihydropyrimidine-5-carbaldehyde (CAS 105161-35-1)
- 3-(((2,4-Difluorophenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione (CAS 369396-96-3)
- 1-Cyclopentyl-4-iodo-5-(propoxymethyl)-1H-pyrazole (CAS 1856058-19-9)
- (2R,4R)-4-fluoro-5-oxopyrrolidine-2-carboxylic acid (CAS 160705-72-6)
- Polymyxin B nonapeptide (CAS 86408-36-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com