Tofacitinib Impurity 208 CAS 1638499-31-6

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.1638499-31-6
Molecular FormulaC14H22N2
Molecular Weight218.34 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Tofacitinib Impurity 208 CAS 1638499-31-6 chemical structure

Description

Tofacitinib Impurity 208 (CAS 1638499-31-6) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2 and a molecular weight of 218.34 g/mol.

Tofacitinib Impurity 208 (C14H22N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC14H22N2
Molecular Weight218.34 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1993
Nitrogen Atoms2

Related Tofacitinib Standards

Recommended Standards

Why CATO?