Tofacitinib Impurity 57 CAS 477600-70-7
| CAS No. | 477600-70-7 |
| Molecular Formula | C14H22N2 |
| Molecular Weight | 218.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Tofacitinib Impurity 57 (C14H22N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Tofacitinib Impurity 57 (CAS 477600-70-7) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2 and a molecular weight of 218.34 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity 57 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H22N2 |
| Molecular Weight | 218.34 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 126 (CAS 384338-23-2)
- Tofacitinib Impurity 208 (CAS 1638499-31-6)
- Tofacitinib Impurity 83 (CAS 1638499-33-8)
- Tofacitinib Impurity 144 (CAS 2091669-67-7)
- Tofacitinib Impurity 233 (CAS CATO-C4X-1079233)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 218 (CAS CATO-C4X-1079218)
- Tofacitinib Impurity 198 (CAS CATO-C4X-1079198)
Recommended Standards
- Artemisinic Aldehyde (CAS 125276-60-0)
- Bromhexine EP Impurity C (CAS 57365-08-9)
- 1,10-Decanedioic-d16 Acid (CAS 73351-71-0)
- 942-91-6 Acetic acid, [(phenylthioxomethyl)thio]- Benzoic acid, carboxymethyl ester Benzoic acid, ester with mercaptoacetic acid Carboxymethyl dithiobenzoate NSC-68200 NSC68200 Thiobenzoyl thioglycolate Thiobenzoylthioacetic acid (CAS 942-91-6)
- Pregabalin Impurity 137 (CAS CATO-C4X-1312137)
- Opicapone impurity 62 (CAS CATO-C4X-240462)
- Regadenoson Impurity 21 (CAS 146-77-0)
- N-(2-Methyl-1-oxo-1-phenylpropan-2-yl)benzamide (CAS 56965-16-3)
- n-Cyclopropyl-2-((3,5-dichlorophenyl)amino)acetamide (CAS 923675-90-5)
- N,3-dimethylimidazol-4-amine (CAS 344323-05-3)
- 4,4'-Thiobis(benzene-1-sulfonyl chloride) (CAS 3119-65-1)
- 2-tert-Butyl-5-nitrophenol (CAS 442847-11-2)
- 1-(4-Bromo-3-fluorophenyl)cyclobutanecarbonitrile (CAS 1314703-96-2)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com