Tofacitinib Impurity 126 CAS 384338-23-2

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.384338-23-2
Molecular FormulaC14H22N2
Molecular Weight218.34 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Tofacitinib Impurity 126 CAS 384338-23-2 chemical structure

Description

CATO supplies Tofacitinib Impurity 126 (CAS 384338-23-2), a pharmacopoeial impurity reference standard (molecular formula C14H22N2, MW 218.34 g/mol) used for the identification and quantification of trace impurities in APIs.

Tofacitinib Impurity 126 (C14H22N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Tofacitinib Impurity 126 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC14H22N2
Molecular Weight218.34 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Nitrogen Atoms2

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