Tofacitinib Impurity 218 CAS CATO-C4X-1079218
| CAS No. | CATO-C4X-1079218 |
| Molecular Formula | C6H7Cl2N3O2 |
| Molecular Weight | 224.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tofacitinib Impurity 218 (CAS CATO-C4X-1079218) is a certified pharmaceutical impurity reference standard with the molecular formula C6H7Cl2N3O2 and a molecular weight of 224.04 g/mol.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Tofacitinib Impurity 218 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 224.04 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity 218 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H7Cl2N3O2 |
| Molecular Weight | 224.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 198 (CAS CATO-C4X-1079198)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 233 (CAS CATO-C4X-1079233)
- Tofacitinib Impurity 137 (CAS 7400-06-8)
- Tofacitinib Impurity 126 (CAS 384338-23-2)
- Tofacitinib Impurity 208 (CAS 1638499-31-6)
- Tofacitinib Impurity 57 (CAS 477600-70-7)
- Tofacitinib Impurity 83 (CAS 1638499-33-8)
Recommended Standards
- 4-Iodocyclohexanone (CAS 31053-10-8)
- Tinidazole Impurity 26 (CAS CATO-C4X-193026)
- 4-Fluoro-3-pentanoylphenylboronic acid (CAS 2096331-08-5)
- 6-Bromoisoquinolin-4-ol (CAS 1015070-56-0)
- Apixaban Impurity 129 (CAS CATO-C4X-1088129)
- Iguratimod Impurity 150 (CAS CATO-C4X-1826150)
- Lornoxicam Impurity 74 (CAS CATO-C4X-201674)
- 2-(Diphenylmethoxy)-N,N,N-trimethylethanaminium Bromide (CAS 31065-89-1)
- 3-(o-Tolyl)isoxazole (CAS 1093649-60-5)
- 4-Chloro-N-(thiophen-2-ylmethyl)benzamide (CAS 332082-86-7)
- Deferiprone Impurity 5 (CAS CATO-C4X-30485)
- 5,4'-Dihydroxy-6,7,3',5'-tetramethoxyflavone (CAS 83133-17-9)
- 1-Amino-8-chloro-2-(p-tolylamino)anthracene-9,10-dione (CAS 88653-24-1)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com