Tofacitinib Impurity 224 CAS 1655430-59-3
| CAS No. | 1655430-59-3 |
| Molecular Formula | C13H19N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Tofacitinib Impurity 224 (CAS 1655430-59-3), a pharmacopoeial impurity reference standard (molecular formula C13H19N5HCl, MW 281.79 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C13H19N5HCl, Tofacitinib Impurity 224 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 281.79 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H19N5 2*HCl |
| Molecular Weight | 281.79 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Abrocitinib Impurity 42 (CAS CATO-C4X-288442)
- Articaine Impurity 19 (CAS 2602451-78-3)
- Methotrexate EP Impurity F (CAS 51865-79-3)
- Metal Elements Mix 16 （Sc、Y、La、Ce、Pr、Nd、Sm、Eu、Gd、Tb、Dy、Ho、Er、Tm、Yb、Lu） (CAS CATO-LINS001305)
- 8-Methoxyphenanthridin-6(5H)-one (CAS 38088-95-8)
- Benzene, 1-(1-methylethenyl)-3-nitro- (CAS 64416-49-5)
- 7-[(tert-Butoxy)carbonyl]-1-oxa-2,7-diazaspiro[4.5]dec-2-ene-3-carboxylic acid (CAS 1160247-01-7)
- 3-Aminopyrazolo[1,5-a]pyridin-4-ol (CAS 340961-96-8)
- (Z)-[1-(Pyrazin-2-yl)ethylidene]amino 3-(trifluoromethyl)benzoate (CAS 866019-14-9)
- Insulin Degludec Impurity 11 (CAS CATO-C4X-215711)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com