Loratadine impurity 22 CAS CATO-C4X-142622
| CAS No. | CATO-C4X-142622 |
| Molecular Formula | C23H25ClN2O4 |
| Molecular Weight | 428.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Loratadine impurity 22 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Loratadine impurity 22 (CAS CATO-C4X-142622, C23H25ClN2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Loratadine impurity 22 (C23H25ClN2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 428.91 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Loratadine impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H25ClN2O4 |
| Molecular Weight | 428.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine impurity 21 (CAS CATO-C4X-142621)
- Loratadine EP Impurity 39 (CAS 609806-38-4)
- Loratadine Impurity 40 (CAS 609806-37-3)
- Loratadine Impurity 65 (CAS CATO-C4X-142665)
- Loratadine Impurity 81 (CAS CATO-C4X-142681)
- Loratadine Impurity 55 (CAS CATO-C4X-142655)
- Loratadine Impurity 53 (CAS CATO-C4X-142653)
- Loratadine Impurity 43 (CAS CATO-C4X-142643)
Recommended Standards
- 7-Benzoyl-11-(2-chlorophenyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (CAS 297160-46-4)
- 4-Chloro-N-(2-(dimethylamino)-4,6-diphenylpyrimidin-5-yl)benzamide (CAS 443315-37-5)
- Melphalan Impurity 27 (CAS CATO-C4X-198827)
- 1-(Phenylsulfonyl)piperidin-4-one O-((4-chlorophenyl)sulfonyl) oxime (CAS 477847-35-1)
- Pemetrexed Impurity 43 (CAS 863767-87-7)
- Melatonin impurity 10 (CAS CATO-C4X-229210)
- Prucalopride Impurity 6 (CAS CATO-C4X-10386)
- tert-butyl 2-{[2-(tert-butoxy)-2-oxoethyl]dimethylsilyl}acetate (CAS 1909318-75-7)
- (N-Me-Phe7)-Neurokinin B trifluoroacetate salt (CAS 110880-53-0)
- tert-Butyl 6-oxo-2,3-diphenylmorpholine-4-carboxylate (CAS 302911-78-0)
- 7-Bromo-6,8-dichloroquinazoline-2,4(1H,3H)-dione (CAS 2742661-31-8)
- 2-(1-Methyl-3-(trifluoromethyl)-1h-pyrazol-5-yl)acetonitrile (CAS 1328640-61-4)
- Bromazepam Impurity 1 (2-(2-Aminobenzoyl)pyridine) (CAS 42471-56-7)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
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