Linagliptin Impurity 46 CAS 668273-75-4
| CAS No. | 668273-75-4 |
| Molecular Formula | C30H36N8O4 |
| Molecular Weight | 572.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Linagliptin Impurity 46 (CAS 668273-75-4, C30H36N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Linagliptin Impurity 46 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 572.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Linagliptin Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H36N8O4 |
| Molecular Weight | 572.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 8 |
Related Linagliptin Standards
- Linagliptin Impurity 123 (CAS CATO-C4X-1101123)
- Linagliptin impurity 143 (CAS 2517759-32-7)
- Linagliptin Impurity 159 (CAS CATO-C4X-1101159)
- Linagliptin Impurity 18 (CAS 668273-74-3)
- Linagliptin Impurity 69 (CAS CATO-C4X-110169)
- Linagliptin Impurity 77 (CAS 1673546-62-7)
- Linagliptin Impurity N13 (CAS 2138392-83-1)
- Linagliptin Impurity 12 (CAS CATO-C4X-110112)
Recommended Standards
- Bradykinin (1-5) (CAS 23815-89-6)
- Atorvastatin Impurity 16 (CAS CATO-C4X-113216)
- Atorvastatin Calcium EP Impurity M (CAS 345891-62-5)
- N1,N2-Ditrityloxalamide (CAS 103389-57-7)
- Metformin Impurity 18 (CAS 58228-69-6)
- Cinacalcet Impurity 99 (CAS CATO-C4X-105999)
- Neratinib Impurity 60 (CAS CATO-C4X-113460)
- Tert-butyl 4-((3-hydroxypropyl)amino)piperidine-1-carboxylate (CAS 864655-26-5)
- cis-Lachnophyllum Ester (CAS 505-01-1)
- 4-(Methylamino)-1,2,5-thiadiazole-3-carbohydrazide (CAS 89125-17-7)
- 5-Bromo-2,4-dichloropyridine (CAS 849937-96-8)
- 5-Amino-N-ethyl-1H-pyrazole-1-carboxamide (CAS 154366-36-6)
- 6-(Furan-2-yl)-3-methyl-1-phenyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 565167-01-3)
- Des-Pro36-Tirzepatide (CAS CATO-CPTD788937)
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