Montelukast Impurity 27 CAS 168214-67-3
| CAS No. | 168214-67-3 |
| Molecular Formula | C29H26ClNO |
| Molecular Weight | 439.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Montelukast Impurity 27 (CAS 168214-67-3), a pharmacopoeial impurity reference standard (molecular formula C29H26ClNO, MW 439.98 g/mol) used for the identification and quantification of trace impurities in APIs.
Montelukast Impurity 27 (C29H26ClNO) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C29H26ClNO |
| Molecular Weight | 439.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Montelukast Standards
- Montelukast Dehydro Impurity (CAS 168214-68-4)
- Montelukast Impurity 32 (CAS 1187586-63-5)
- Montelukast Impurity 37 (CAS CATO-C4X-103137)
- Montelukast Impurity 29 (CAS 184764-13-4)
- Montelukast Impurity N19 (CAS 150026-73-6)
- Montelukast Impurity 11 (CAS 120578-04-3)
- Montelukast Impurity 56 (CAS 1100617-38-6)
- Montelukast 3-Oxo Benzoate (CAS 149968-11-6)
Recommended Standards
- N-(1-(4-Chlorophenyl)ethyl)-2-((4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 869866-06-8)
- 2-Imino-6,8-diiodo-2H-chromene-3-carboxamide (CAS 1823984-45-7)
- Loratadine Impurity 41 (CAS CATO-C4X-142641)
- (E)-2-(3-(1,1-Dimethyl-1,3,4,5-tetrahydrobenzo-[c]oxepin-3-yl)styryl)-7-chloroquinoline 1040351-42-5 (CAS 1040351-42-5)
- Terazosin Impurity 18 (CAS CATO-C4X-134918)
- Crisaborole Impurity 36 (CAS 90178-72-6)
- Etrasimod impurity 15 (CAS CATO-C4X-321415)
- 3-(4-Bromo-2-methoxyphenoxy)propanoic acid (CAS 81258-24-4)
- 29079-00-3 4-Ethynylbiphenyl Biphenyl, 4-ethynyl- 4-Ethynyl-1,1'-biphenyl 4-05-00-02280 (Beilstein Handbook Reference) 1,1'-Biphenyl, 4-ethynyl p-Biphenylacetylene 4-Biphenylacetylene 4-Biphenylylacetylene BRN 1927901 LY 81979 (CAS 29079-00-3)
- 2-Methyl-1h-benzo[d]imidazole-5-sulfonamide (CAS 57476-34-3)
- Isophoronediamine(Mixture of cis and trans isomers) (CAS 2855-13-2)
- n-(3,3,3-Trifluoropropyl)cyclopentanamine (CAS 1183610-06-1)
- Mefenamic Acid Impurity 3 (CAS 83-41-0)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
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