Loratadine Impurity 76 CAS CATO-C4X-142676
| CAS No. | CATO-C4X-142676 |
| Molecular Formula | C19H21ClN2 |
| Molecular Weight | 312.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Loratadine Impurity 76 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Loratadine Impurity 76 (CAS CATO-C4X-142676) is a certified pharmaceutical impurity reference standard with the molecular formula C19H21ClN2 and a molecular weight of 312.84 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Loratadine Impurity 76 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 312.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Loratadine Impurity 76 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H21ClN2 |
| Molecular Weight | 312.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine EP Impurity D (CAS 100643-71-8)
- Loratadine Impurity 53 (CAS 107285-30-3)
- Loratadine Impurity 30 (CAS 1346600-30-3)
- Loratadine EP Impurity G (CAS 38092-89-6)
- Loratadine Impurity 94 (CAS CATO-C4X-142694)
- Loratadine Impurity 77 (CAS 170727-68-1)
- Loratadine Impurity 28 (CAS 3964-81-6)
- Loratadine impurity 87 (CAS 130642-54-5)
Recommended Standards
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Why CATO?
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