Levofloxacin Descarboxy Impurity（Levofloxacin EP Impurity E） CAS 178964-53-9
| CAS No. | 178964-53-9 |
| Molecular Formula | C17H20FN3O2 |
| Molecular Weight | 317.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 317.36 g/mol gives Levofloxacin Descarboxy Impurity（Levofloxacin EP Impurity E） distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Levofloxacin Descarboxy Impurity（Levofloxacin EP Impurity E） (CAS 178964-53-9, C17H20FN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Levofloxacin Descarboxy Impurity（Levofloxacin EP Impurity E） is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 317.36 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H20FN3O2 |
| Molecular Weight | 317.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Levofloxacin Standards
- Levofloxacin Impurity 100 (CAS 104600-15-9)
- Levofloxacin impurity 01 (CAS 154228-18-9)
- Levofloxacin Impurity 94 (CAS CATO-C4X-137194)
- Levofloxacin Impurity 17 (CAS CATO-C4X-137117)
- Levofloxacin impurity 66 (CAS CATO-C4X-137166)
- Levofloxacin Impurity 44 (CAS 94714-58-6)
- Levofloxacin Impurity 21 (CAS 1797510-34-9)
- Levofloxacin Impurity 26 (CAS 106939-34-8)
Recommended Standards
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