Celecoxib Impurity 40 CAS 4392-54-5
| CAS No. | 4392-54-5 |
| Molecular Formula | C6H9N3O2S |
| Molecular Weight | 187.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 187.22 g/mol gives Celecoxib Impurity 40 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Celecoxib Impurity 40 (CAS 4392-54-5, C6H9N3O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Celecoxib Impurity 40 (C6H9N3O2S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 187.22 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Celecoxib Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H9N3O2S |
| Molecular Weight | 187.22 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Celecoxib Standards
- Celecoxib Impurity 38 (CAS 131774-72-6)
- Celecoxib Impurity 45 (CAS 90824-33-2)
- Celecoxib Impurity N3 (CAS 877-67-8)
- Celecoxib Impurity N4 (CAS 90829-71-3)
- Celecoxib Impurity 34 (CAS 24939-24-0)
- Celecoxib Impurity 35 (CAS 98-64-6)
- Celecoxib Impurity 3 (CAS 53578-01-1)
- Celecoxib Impurity 27 (CAS 343853-74-7)
Recommended Standards
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- 2-(1-Piperazinyl)-4-thiazolecarbonitrile (CAS 1226516-30-8)
- Tert-butyl (2,2,3,3,4,4,4-heptafluorobutyl) carbonate (CAS 1980086-63-2)
- 4628-94-8 Dipotassium 1,3,4-thiadiazole-2,5-dithiolate 1,3,4-Thiadiazolidine-2,5-dithione, potassium salt (1:2) 1,3,4-Thiadiazolidine-2,5-dithione, dipotassium salt 2,5-Dimercapto-1,3,4-thiadiazole, dipotassium salt EINECS 225-043-4 (CAS 4628-94-8)
- n-[(4-bromothiophen-2-yl)methyl]-2-chloro-n-methylacetamide (CAS 1183046-17-4)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
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