Apremilast Impurity 3 CAS 1802246-60-1
| CAS No. | 1802246-60-1 |
| Molecular Formula | C30H27N3O9S |
| Molecular Weight | 605.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apremilast Impurity 3.
Apremilast Impurity 3 (CAS 1802246-60-1) is a certified pharmaceutical impurity reference standard with the molecular formula C30H27N3O9S and a molecular weight of 605.62 g/mol.
Based on its molecular formula C30H27N3O9S, Apremilast Impurity 3 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 605.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H27N3O9S |
| Molecular Weight | 605.62 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Apremilast Standards
- Apremilast Impurity 124 (CAS 2741194-01-2)
- Apremilast Impurity 24 (CAS 2487573-01-1)
- Apremilast Impurity 53 (CAS CATO-C4X-100953)
- Apremilast Impurity 6 (CAS 1809170-71-5)
- Apremilast Impurity 7 (CAS 2096492-41-8)
- Apremilast Impurity 115 (CAS 1384814-94-1)
- Apremilast Impurity 32 (CAS CATO-C4X-100932)
- Apremilast Impurity 44 (CAS 2096492-44-1)
Recommended Standards
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- Piperazine Impurity 8 (CAS 769083-63-8)
- Ivermectin EP Impurity C (CAS 65195-57-5)
- Metazachlor Impurity 3 (CAS 2345-61-1)
- 1-(2-(Dimethylamino)ethyl)-3-phenylurea (CAS 14569-77-8)
- 1-Tosyl-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde (CAS 479553-03-2)
- 5-Benzyl-4-propyl-4H-1,2,4-triazol-3-yl hydrosulfide (CAS 663181-82-6)
- 89186-80-1 Ethyl acetoacetate-3,4-13C2 DTXSID20480002 (CAS 89186-80-1)
- N-(3-((3-(dimethylamino)propyl)amino)propyl)nicotinamide (CAS 404013-89-4)
- Bensulide Impurity 3 (CAS 107-56-2)
- Uremic Pentapeptide (CAS 71494-20-7)
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