Losartan Impurity 20 CAS 1846587-44-7

Description

Compared with other compounds in its class, the molecular weight of 809.79 g/mol gives Losartan Impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Losartan Impurity 20 (CAS 1846587-44-7) is a certified pharmaceutical impurity reference standard with the molecular formula C44H42Cl2N12 and a molecular weight of 809.79 g/mol.

Losartan Impurity 20 (C44H42Cl2N12) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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