Losartan Impurity 33 CAS CATO-C4X-168333
| CAS No. | CATO-C4X-168333 |
| Molecular Formula | C44H44Cl2N12O |
| Molecular Weight | 827.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Losartan Impurity 33 (CAS CATO-C4X-168333, C44H44Cl2N12O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Losartan Impurity 33 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 827.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Losartan Impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C44H44Cl2N12O |
| Molecular Weight | 827.81 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 28.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 12 |
Related Losartan Standards
- Losartan EP Impurity L (CAS 230971-71-8)
- Losartan EP Impurity M (CAS 230971-72-9)
- Losartan Potassium EP Impurity M (CAS 212316-88-6（free base）)
- Losartan alpha-Butyl-Losartan Aldehyde Adduct (CAS 1159977-48-6)
- Losartan Impurity 20 (CAS 1846587-44-7)
- Losartan Impurity 52 (CAS CATO-C4X-168352)
- Losartan impurity 32 (CAS CATO-C4X-168332)
- Losartan Impurity N3 (CAS 133910-00-6)
Recommended Standards
- ((Butylstannanetriyl)tris(sulfanediyl))tris(ethane-2,1-diyl) trinonanoate (CAS 68298-36-2)
- (p-Benzoquinone)bis(triphenylphosphine)platinum (CAS 32648-87-6)
- ((Butylstannanetriyl)tris(sulfanediyl))tris(ethane-2,1-diyl) tris(3,5,5-trimethylhexanoate) (CAS 68298-43-1)
- ([1,1′-Biphenyl]-2-yldicyclohexylphosphine)[1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamidato-κN]gold (CAS 1016161-75-3)
- Isavuconazole Impurity 79 (CAS 483340-20-1)
- Selexipag Impurity 5 (CAS 2287345-22-4)
- Revefenacin impurity 104 (CAS 743460-48-2（free base）)
- 3-(4-Bromo[1,1-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol (CAS 56181-82-9)
- 2-Cyano-3-(4-methyl-5-thiazolyl)propanoic Acid (CAS 2044707-03-9)
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- 4-Chloro-N-(4-hydroxyphenyl)benzenesulfonamide (CAS 63301-13-3)
- Nintedanib Impurity 66 (CAS 707-07-3)
- 5-Methoxy-N,N-diisopropyltryptamine Hydrochloride (CAS 2426-63-3)
- Eosinophilotactic Peptide (CAS 61756-28-3)
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