Losartan EP Impurity M CAS 230971-72-9
| CAS No. | 230971-72-9 |
| Molecular Formula | C44H44Cl2N12O |
| Molecular Weight | 827.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Losartan EP Impurity M (CAS 230971-72-9, C44H44Cl2N12O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Losartan EP Impurity M is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 827.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C44H44Cl2N12O |
| Molecular Weight | 827.81 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 28.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2022 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 12 |
Related Losartan Standards
- Losartan EP Impurity L (CAS 230971-71-8)
- Losartan Impurity 33 (CAS CATO-C4X-168333)
- Losartan Potassium EP Impurity M (CAS 212316-88-6（free base）)
- Losartan alpha-Butyl-Losartan Aldehyde Adduct (CAS 1159977-48-6)
- Losartan Impurity 20 (CAS 1846587-44-7)
- Losartan Impurity 52 (CAS CATO-C4X-168352)
- Losartan impurity 32 (CAS CATO-C4X-168332)
- Losartan Impurity N3 (CAS 133910-00-6)
Recommended Standards
- (p-Benzoquinone)bis(triphenylphosphine)platinum (CAS 32648-87-6)
- ([1,1′-Biphenyl]-2-yldicyclohexylphosphine)[1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamidato-κN]gold (CAS 1016161-75-3)
- ((Butylstannanetriyl)tris(sulfanediyl))tris(ethane-2,1-diyl) trinonanoate (CAS 68298-36-2)
- (S,R,S)-AHPC-PEG6-C4-Cl (CAS 1835705-59-3)
- Benzocaine EP Impurity H (CAS 619-45-4)
- Doxofylline impurity 47 (CAS 180262-60-6)
- Rebamipide impurity 21 (CAS 452322-61-1)
- 4-(chloromethyl)-N,N-dimethylbenzamide (CAS 121083-51-0)
- 6-(4-Chlorophenyl)-2-(methylsulfanyl)pyridine-3-carbonitrile (CAS 252059-07-7)
- 2-(4-Chlorophenoxy)-N'-[(1E)-[4-(trifluoromethoxy)phenyl]methylidene]acetohydrazide (CAS 868630-56-2)
- methyl 2-oxo-3-(propan-2-yl)-octahydro-1,3-benzoxazole-5-carboxylate (CAS 2114521-57-0)
- 2-((Cyanomethyl)thio)-N,3-diisobutyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide (CAS 946324-06-7)
- 1-[4-(aminomethyl)piperidin-1-yl]-2,2,2-trifluoroethan-1-one hydrochloride (CAS 1354961-00-4)
- Insulin Degludec Impurity 6 (CAS CATO-C4X-21576)
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