Lenvatinib Impurity 43 CAS 1882873-21-3
| CAS No. | 1882873-21-3 |
| Molecular Formula | C21H17ClN4O3 |
| Molecular Weight | 408.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lenvatinib Impurity 43.
Lenvatinib Impurity 43 (CAS 1882873-21-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H17ClN4O3 and a molecular weight of 408.84 g/mol.
Lenvatinib Impurity 43 (C21H17ClN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lenvatinib Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H17ClN4O3 |
| Molecular Weight | 408.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 180 (CAS CATO-C4X-1140180)
- Lenvatinib Impurity 89 (CAS CATO-C4X-114089)
- Lenvatinib Impurity 30 (CAS 417717-04-5)
- Lenvatinib Impurity 92 (CAS 2143930-76-9)
- Lenvatinib Impurity 121 (CAS CATO-C4X-1140122)
- Lenvatinib Impurity 172 (CAS CATO-C4X-1140172)
- Lenvatinib Impurity 4 (CAS 417719-45-0)
- Lenvatinib Impurity 1 (CAS 417714-14-8)
Recommended Standards
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- [4-amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol (CAS 588-36-3)
- 1-(4-Fluorophenyl)-2-(3-nitro-1h-pyrazol-1-yl)ethan-1-one (CAS 1240568-08-4)
- [[2-(Cyclopentylamino)-2-oxoethyl](phenyl)amino]-acetic acid (CAS 1142205-25-1)
- 4-Benzyl-1-piperazine-carboxylic acid amidehydrochloride (CAS 89026-61-9)
- N-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)benzamide (CAS 338401-46-0)
- Insulin Degludec Impurity 11 (CAS CATO-C4X-215711)
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