Lenvatinib Impurity 121 CAS CATO-C4X-1140122
| CAS No. | CATO-C4X-1140122 |
| Molecular Formula | C20H18ClN3O5 |
| Molecular Weight | 415.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lenvatinib Impurity 121 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lenvatinib Impurity 121 (CAS CATO-C4X-1140122, C20H18ClN3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lenvatinib Impurity 121 (C20H18ClN3O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H18ClN3O5 |
| Molecular Weight | 415.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Lenvatinib Standards
- Lenvatinib Impurity 92 (CAS 2143930-76-9)
- Lenvatinib Impurity 30 (CAS 417717-04-5)
- Lenvatinib Impurity 89 (CAS CATO-C4X-114089)
- Lenvatinib Impurity 43 (CAS 1882873-21-3)
- Lenvatinib Impurity 180 (CAS CATO-C4X-1140180)
- Lenvatinib Impurity 113 (CAS CATO-C4X-1140113)
- Lenvatinib Impurity 2 (CAS CATO-C4X-11402)
- Lenvatinib Impurity 29 (CAS 417717-21-6)
Recommended Standards
- 5-Methyl-2-oxotetrahydrofuran-3-carbonitrile (CAS 76263-39-3)
- N-(3-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)methyl)-2,4-difluorophenyl)propane-1-sulfonamide (CAS 1021854-28-3)
- 3-(4-Chlorophenyl)-6,7-diphenyl-2H-oxazolo[3,2-a][1,3,5]triazine-2,4(3H)-dione (CAS 35629-68-6)
- (3-(2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethoxy)phenyl)methanol (CAS 338409-27-1)
- Venetoclax Impurity 64 (CAS CATO-C4X-249564)
- Ciprofloxacin EP Impurity A (CAS 86393-33-1)
- Ilaprazole Impurity 127 (CAS CATO-C4X-1130127)
- 4,6-Dibromobenzo[d][1,3]dioxol-5-amine (CAS 1706433-57-9)
- 2-Bromo-N,N-dimethyl-1H-imidazole-1-sulfonamide (CAS 1239205-21-0)
- n-(4-Methoxybenzyl)-2-phenylethan-1-amine (CAS 3241-00-7)
- tert-Butyl 1-(bromomethyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate (CAS 2137780-11-9)
- (Z)-2-Benzylidenesuccinic acid (CAS 65756-81-2)
- 2-Propenoic acid, butyl ester, polymer with 1,3-butadiene and 2-propenenitrile (CAS 25838-41-9)
- Peptide Impurity 15 (CAS 1227750-69-7)
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