Lenvatinib Impurity 92 CAS 2143930-76-9
| CAS No. | 2143930-76-9 |
| Molecular Formula | C20H19ClN4O4 |
| Molecular Weight | 414.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Lenvatinib Impurity 92 (CAS 2143930-76-9, C20H19ClN4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lenvatinib Impurity 92 (C20H19ClN4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19ClN4O4 |
| Molecular Weight | 414.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 121 (CAS CATO-C4X-1140122)
- Lenvatinib Impurity 30 (CAS 417717-04-5)
- Lenvatinib Impurity 89 (CAS CATO-C4X-114089)
- Lenvatinib Impurity 43 (CAS 1882873-21-3)
- Lenvatinib Impurity 180 (CAS CATO-C4X-1140180)
- Lenvatinib Impurity 113 (CAS CATO-C4X-1140113)
- Lenvatinib Impurity 2 (CAS CATO-C4X-11402)
- Lenvatinib Impurity 29 (CAS 417717-21-6)
Recommended Standards
- Hafnium(IV) i-propoxide monoisopropylate, 99% (CAS 2171-99-5)
- N-((2-Chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)-4-(trifluoromethyl)aniline (CAS 1378490-61-9)
- Ethyl 3-(4-(2-((3-chlorophenyl)amino)-2-oxoethoxy)-3-methoxyphenyl)-2-cyanoacrylate (CAS 483276-95-5)
- (6aR,8S,10aS)-10a-(4-chlorophenylsulfonyl)-1,4-difluoro-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-8-ol (CAS 944949-06-8)
- Olmesartan Impurity 47 (CAS 1048948-15-7)
- Cefoxitin EP Impurity E (CAS 2395025-32-6)
- Paroxetine Impurity 44 (CAS 317323-77-6)
- [1-(2-Fluoro-ethyl)-1h-pyrazol-3-yl]-methanol (CAS 1427021-99-5)
- tert-Butyl 4-(chloromethyl)thiazol-2-ylcarbamate (CAS 892952-70-4)
- 5-Carboxymethylaminomethyluridine (CAS 69181-26-6)
- 4-Ethylphenyl chloroformate (CAS 68622-08-2)
- N-{2-[(4-bromophenyl)sulfanyl]ethyl}-4-fluorobenzamide (CAS 338955-70-7)
- Methyl 4-bromo-5-chloro-2-methylbenzoate (CAS 1427424-00-7)
- α Bag Cell Peptide (1-9) (CAS 87549-52-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com