Hydrochlorothiazide Impurity 18 CAS 89813-56-9
| CAS No. | 89813-56-9 |
| Molecular Formula | C7H6ClN3O5S2 |
| Molecular Weight | 311.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Hydrochlorothiazide Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Hydrochlorothiazide Impurity 18 (CAS 89813-56-9) is a certified pharmaceutical impurity reference standard with the molecular formula C7H6ClN3O5S2 and a molecular weight of 311.72 g/mol.
Hydrochlorothiazide Impurity 18 (C7H6ClN3O5S2) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H6ClN3O5S2 |
| Molecular Weight | 311.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 31 (CAS 890-67-5)
- Hydrochlorothiazide Impurity 24 (CAS 1025-75-8)
- Hydrochlorothiazide Impurity 10 (CAS CATO-C4X-117710)
- Hydrochlorothiazide Impurity 29 (CAS 1753-71-5)
- Hydrochlorothiazide Impurity 14 (CAS 1668-63-9)
- Hydrochlorothiazide impurity 45 (CAS CATO-C4X-117745)
- Hydrochlorothiazide impurity 46 (CAS CATO-C4X-117746)
- Hydrochlorothiazide Impurity 34 (CAS CATO-C4X-117734)
Recommended Standards
- 501925-31-1 1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea Urea, N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)- PNU-120596 NSC 216666 PNU 120596 (CAS 501925-31-1)
- Asenapine Impurity 7 (CAS 129385-61-1)
- Methyl 2-((4-chlorophenyl)carbamoyl)-6-oxohexahydropyridazine-4-carboxylate (CAS 339096-86-5)
- (2E)-3-(3-Chlorophenyl)-2-{5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-1,2,4-triazol-3-yl}prop-2-enenitrile (CAS 1164520-60-8)
- Isavuconazole Impurity 131 Iodization HCl (Mixture of Diastereomers) (CAS CATO-C4X-1236131)
- Itopride Impurity 21 (CAS 199679-32-8)
- Repaglinide Impurity 10 (CAS CATO-C4X-118610)
- 6-Chloro-2-(chloromethyl)-5-(difluoromethyl)nicotinaldehyde (CAS 1806944-96-6)
- tert-Butyl thiomorpholine-4-carboxylate 1,1-dioxide (CAS 215791-95-0)
- 2-(tert-Butyl)piperazine (CAS 292063-44-6)
- 4-Chloro-N'-(4,6-dimethyl-3-(1H-pyrrol-1-yl)thieno[2,3-b]pyridine-2-carbonyl)benzenesulfonohydrazide (CAS 478029-15-1)
- (S)-1-(pyridin-2-yl)propan-1-ol (CAS 18209-34-2)
- 6-Bromo-2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one (CAS 337463-88-4)
- Vialox Peptide(Pentapeptide-3) (CAS 135679-88-8)
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