Osimertinib Impurity N4 CAS 1956306-73-2
| CAS No. | 1956306-73-2 |
| Molecular Formula | C20H17N5O4 |
| Molecular Weight | 391.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Osimertinib Impurity N4 (CAS 1956306-73-2) is a certified pharmaceutical impurity reference standard with the molecular formula C20H17N5O4 and a molecular weight of 391.38 g/mol.
Osimertinib Impurity N4 (C20H17N5O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Osimertinib Impurity N4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H17N5O4 |
| Molecular Weight | 391.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 5 |
Related Osimertinib Standards
- Osimertinib Impurity 40 (CAS CATO-C4X-204540)
- Osimertinib Impurity 90 (CAS CATO-C4X-204590)
- Osimertinib Impurity 73 (CAS CATO-C4X-204573)
- Osimertinib Impurity 114 (CAS CATO-C4X-2045114)
- Osimertinib Impurity 36 (CAS CATO-C4X-204536)
- Osimertinib Impurity 53 (CAS CATO-C4X-204553)
- Osimertinib Impurity 54 (CAS 27065-95-8)
- Osimertinib Impurity 16 (CAS 2044704-62-1)
Recommended Standards
- 1-((5-Cyclopentyl-1,2,4-oxadiazol-3-yl)methyl)-5-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)pyridin-2(1H)-one (CAS 1396855-78-9)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4,5-trifluorophenyl)methanone (CAS 898781-08-3)
- Sitafloxacin Impurity 87 (CAS 500295-84-1)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4,5-trifluorophenyl)methanone (CAS 898762-43-1)
- Pyridoxine Impurity 13 (CAS CATO-C4X-187713)
- Diltiazem Impurity N2 (CAS 42399-50-8)
- Relugolix Impurity 18 (CAS CATO-C4X-242918)
- 2-Trifluoromethyl-4-thiazolecarboxaldehyde (CAS 133046-48-7)
- 4-Methyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)pyridin-3-amine (CAS 1341162-36-4)
- 5-(chloromethyl)-1-[4-(trifluoromethyl)phenyl]-1H-1,2,3,4-tetrazole (CAS 1094265-93-6)
- 2-Cyclopropyl-3-fluoroaniline (CAS 2366994-64-9)
- Sunitinib-d10 (CAS 1126721-82-1)
- 1189467-51-3 2,5-(dimethoxy-d6)-4-methylphenethylamine hydrochloride (CAS 1189467-51-3)
- Peptide Impurity 15 (CAS 1227750-69-7)
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