Osimertinib Impurity 53 CAS CATO-C4X-204553
| CAS No. | CATO-C4X-204553 |
| Molecular Formula | C19H14FN5O3 |
| Molecular Weight | 379.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Osimertinib Impurity 53 (CAS CATO-C4X-204553), a pharmacopoeial impurity reference standard (molecular formula C19H14FN5O3, MW 379.34 g/mol) used for the identification and quantification of trace impurities in APIs.
Osimertinib Impurity 53 (C19H14FN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Osimertinib Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H14FN5O3 |
| Molecular Weight | 379.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Osimertinib Standards
- Osimertinib Impurity 36 (CAS CATO-C4X-204536)
- Osimertinib Impurity 89 (CAS CATO-C4X-204589)
- Osimertinib Impurity 76 (CAS CATO-C4X-204576)
- Osimertinib Impurity 77 (CAS CATO-C4X-204577)
- Osimertinib Impurity 17 (CAS CATO-C4X-204517)
- Osimertinib Impurity N4 (CAS 1956306-73-2)
- Osimertinib Impurity 40 (CAS CATO-C4X-204540)
- Osimertinib Impurity 90 (CAS CATO-C4X-204590)
Recommended Standards
- 6-((1-(3-Fluoro-5-(trifluoromethyl)benzyl)piperidin-4-yl)amino)pyridazine-3-carbonitrile (CAS 1032714-06-9)
- Cefuroxime Impurity 99 (CAS CATO-C4X-124599)
- 4-bromo-6-chloro-2-fluoro-3-iodobenzoic acid (CAS 1160573-32-9)
- Ethyl (5-amino-3-(4-(trifluoromethyl)phenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamate (CAS 82586-03-6)
- Butenafine Impurity 22 (CAS CATO-C4X-159622)
- Hydrochlorothiazide impurity 45 (CAS CATO-C4X-117745)
- Venlafaxine Impurity 76 (CAS CATO-C4X-143476)
- 4,6-Dichloro-2-(chloromethyl)pyrimidine (CAS 19875-05-9)
- Clomifene EP Impurity C HCl (CAS 5635-70-1)
- 2-(6-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)acetic acid (CAS 1355173-49-7)
- 3-(2-Ethoxyphenyl)acrylaldehyde (CAS 1268322-98-0)
- 2-(4-Amino-3,5-dimethyl-1h-pyrazol-1-yl)acetamide (CAS 1152950-63-4)
- N-{4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}pentanamide (CAS 478079-26-4)
- Fas C- Terminal Tripeptide (CAS 189109-90-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com