Osimertinib Impurity 40 CAS CATO-C4X-204540
| CAS No. | CATO-C4X-204540 |
| Molecular Formula | C20H16FN5O3 |
| Molecular Weight | 393.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 393.37 g/mol gives Osimertinib Impurity 40 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Osimertinib Impurity 40 (CAS CATO-C4X-204540, C20H16FN5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Osimertinib Impurity 40 (C20H16FN5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Osimertinib Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H16FN5O3 |
| Molecular Weight | 393.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Osimertinib Standards
- Osimertinib Impurity 90 (CAS CATO-C4X-204590)
- Osimertinib Impurity N4 (CAS 1956306-73-2)
- Osimertinib Impurity 73 (CAS CATO-C4X-204573)
- Osimertinib Impurity 114 (CAS CATO-C4X-2045114)
- Osimertinib Impurity 54 (CAS 27065-95-8)
- Osimertinib Impurity 16 (CAS 2044704-62-1)
- Osimertinib Impurity 66 (CAS CATO-C4X-204566)
- Osimertinib Impurity 36 (CAS CATO-C4X-204536)
Recommended Standards
- Levofloxacin Impurity 53 (CAS CATO-C4X-137153)
- tert-Butyl [Bis(4-methoxyphenyl)phosphinyloxy]carbamate (CAS 619333-95-8)
- 3-(6-(N,N-diethylsulfamoyl)-2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)propanoic acid (CAS 1171865-50-1)
- 6-[1-(4-Fluorophenyl)-1H-pyrazol-5-yl]-2-(3-methoxyphenyl)-4-methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione (CAS 321538-37-8)
- Tibolone EP Impurity A (CAS CATO-C4X-240312)
- Cinacalcet Impurity 48 (CAS 10420-89-0)
- Pomalidomide Impurity 57 (CAS CATO-C4X-135457)
- 2-hydroxy-S-(1H-pyrazol-4-yl)ethane-1-sulfonamido (CAS 1183476-16-5)
- 2-Bromo-1-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone (CAS 223785-85-1)
- Methyl 4-aminothieno[2,3-d]pyrimidine-6-carboxylate (CAS 155087-15-3)
- 5-Methylnonan-1-ol (CAS 2768-16-3)
- 2-Phenylethyl 2-(methylamino)benzoate (CAS 1308361-72-9)
- 1-Bromo-3-methylimidazo[1,5-c]pyrimidin-5-amine (CAS 2306274-36-0)
- Biotinyl-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802086-28-7)
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