Ticagrelor impurity 175 CAS 197590-48-0
| CAS No. | 197590-48-0 |
| Molecular Formula | C8H12N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Ticagrelor impurity 175 is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 204.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Ticagrelor impurity 175 (CAS 197590-48-0, C8H12N2O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ticagrelor impurity 175 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12N2O2 HCl |
| Molecular Weight | 204.65 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2013 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ticagrelor Standards
- Ticagrelor Impurity N40 (CAS 1006376-60-8)
- Ticagrelor Impurity 88 (CAS 1006376-61-9)
- Ticagrelor Impurity 152 (CAS 1006376-62-0)
- Ticagrelor Impurity 121 (CAS 1006614-49-8)
- Ticagrelor impurity 84（trans） (CAS 1006614-51-2)
- Ticagrelor Impurity 113 (CAS 1156575-52-8)
- Ticagrelor impurity 161 (CAS 1157692-93-7)
- Ticagrelor Impurity 168 (CAS 1207276-00-3(free base))
Recommended Standards
- Oxaprozin Impurity 1 (CAS 642-04-6)
- Mosapride Impurity 40 (CAS CATO-C4X-104440)
- Isepamicin Impurity 7 (CAS CATO-C4X-31117)
- Atrasentan Impurity 89 (CAS 1059043-39-8)
- Tert-butyl 1-(piperidin-4-yl)-2-azaspiro[3.3]Heptane-2-carboxylate (CAS 2095410-45-8)
- N-[(2R)]-1-amino-3-(4-nitrophenyl)propyl]-1,2-cyclohexanediamine TriHCl (CAS 905825-54-9)
- 5-(2-furyl)isoxaZole-3-carbohydrazide (CAS 90110-76-2)
- 2-(2,6-DIchloro-phenyl)-1,2-dihydropyrazolo[3,4-c]pyridin-3-one (CAS 131373-86-9)
- N-(4-methoxybenzyl)-1,2,5-trimethylpiperidin-4-amine (CAS 302557-63-7)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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