Lapatinib Impurity 8 CAS 202198-16-1
| CAS No. | 202198-16-1 |
| Molecular Formula | C21H16IN3O |
| Molecular Weight | 453.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Lapatinib Impurity 8 (CAS 202198-16-1) is a certified pharmaceutical impurity reference standard with the molecular formula C21H16IN3O and a molecular weight of 453.28 g/mol.
The molecular framework of Lapatinib Impurity 8 (C21H16IN3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Lapatinib Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H16IN3O |
| Molecular Weight | 453.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 3 |
Related Lapatinib Standards
- Lapatinib Impurity 11 (CAS 231278-83-4)
- Lapatinib Impurity 6 (CAS 231278-25-4)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Lapatinib Impurity 14 (CAS 697299-82-4)
- Lapatinib Impurity 19 (CAS 320337-48-2)
- Lapatinib Impurity 12 (CAS 202196-46-1)
Recommended Standards
- 7-(Benzyloxy)-2-(4-bromophenyl)-3-hydroxy-5-methoxy-4h-chromen-4-one (CAS 1402931-94-5)
- Rebamipide Impurity 37 (CAS 1984832-97-4)
- Indapamide Impurity 36 (CAS CATO-C4X-140036)
- 1,4,5,8-Tetraamino-2-(benzyloxy)-6-bromoanthracene-9,10-dione (CAS 88602-99-7)
- Eltrombopag Impurity 86 (CAS CATO-C4X-119886)
- Thiamine EP impurity B HCl (CAS 49614-72-4)
- Capivasertib Impurity 13 (CAS CATO-C4X-331213)
- 1-Benzyl-N-methyl-1H-pyrazol-4-amine dihydrochloride (CAS 28466-70-8)
- Ethyl 2-morpholino-2-(2-(2-(trifluoromethyl)phenyl)hydrazono)acetate (CAS 851169-28-3)
- (8α,9R)-9-Hydroxy-1-[2-[(4-methoxyphenyl)amino]-2-oxoethyl]cinchonanium bromide (CAS 2380293-66-1)
- 2-(3-Chlorophenyl)thiophen-3-amine (CAS 183676-99-5)
- (E)-N-(3,4-dimethylphenyl)-3-(naphthalen-1-yl)acrylamide (CAS 328026-72-8)
- 4-Methoxy-5-(methoxymethyl)-1H-pyrazol-3(2H)-one (CAS 92214-38-5)
- Semaglutide Impurity 115 (CAS CATO-C4X-2226115)
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