Lapatinib Impurity 12 CAS 202196-46-1
| CAS No. | 202196-46-1 |
| Molecular Formula | C26H19N3O3 |
| Molecular Weight | 421.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lapatinib Impurity 12 (CAS 202196-46-1) is a certified pharmaceutical impurity reference standard with the molecular formula C26H19N3O3 and a molecular weight of 421.45 g/mol.
Lapatinib Impurity 12 (C26H19N3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lapatinib Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H19N3O3 |
| Molecular Weight | 421.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Nitrogen Atoms | 3 |
Related Lapatinib Standards
- Lapatinib Impurity 8 (CAS 202198-16-1)
- Lapatinib Impurity 11 (CAS 231278-83-4)
- Lapatinib Impurity 6 (CAS 231278-25-4)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Lapatinib Impurity 14 (CAS 697299-82-4)
- Lapatinib Impurity 19 (CAS 320337-48-2)
Recommended Standards
- Tadalafil Impurity 32 (CAS CATO-C4X-108732)
- Topotecan Impurity 3 (CAS CATO-C4X-17693)
- 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide (CAS 199666-03-0)
- Cefminox Impurity 40 (CAS CATO-C4X-192640)
- Piroxicam impurity 24 (CAS 87234-24-0)
- Butalbital Impurity 2 (CAS 3146-66-5)
- Ramelteon Impurity 10 HCl (CAS 1053239-39-6)
- 3-(4-Amino-3,5-dimethyl-1h-pyrazol-1-yl)-2,2-dimethylpropanoic acid (CAS 1509710-66-0)
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- 4-Fluoro-4'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261996-98-8)
- N-(4-bromo-3-fluorophenyl)thietan-3-amine (CAS 1863580-93-1)
- (2R,3R,4S,5S,6S)-2-(Acetoxymethyl)-6-hydroxytetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 22860-22-6)
- Semaglutide impurity 29 (CAS 110990-08-4)
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