Lapatinib Impurity 14 CAS 697299-82-4
| CAS No. | 697299-82-4 |
| Molecular Formula | C26H20ClFN4O2 |
| Molecular Weight | 474.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 474.91 g/mol gives Lapatinib Impurity 14 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Lapatinib Impurity 14 (CAS 697299-82-4), a pharmacopoeial impurity reference standard (molecular formula C26H20ClFN4O2, MW 474.91 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lapatinib Impurity 14 (C26H20ClFN4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Lapatinib Impurity 14 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H20ClFN4O2 |
| Molecular Weight | 474.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Lapatinib Standards
- Lapatinib Impurity 19 (CAS 320337-48-2)
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
- Lapatinib Impurity 6 (CAS 231278-25-4)
- Lapatinib Impurity 7 (CAS 320337-46-0)
- Lapatinib Impurity 11 (CAS 231278-83-4)
- Lapatinib Impurity 8 (CAS 202198-16-1)
Recommended Standards
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- 1,4,7,10-Tetrakis(pyridin-2-ylmethyl)-1,4,7,10-tetraazacyclododecane (CAS 185130-32-9)
- ZnAF-1F (CAS 443302-08-7)
- 2-(4-Chlorophenyl)-4-(4-nitrobenzylidene)oxazol-5(4H)-one (CAS 90124-89-3)
- 2-Phenethyltetrahydrofuran (CAS 2429-96-1)
- 4-Fluoro-N-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide (CAS 124655-18-1)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com