Lapatinib Impurity 26 CAS CATO-C4X-119126
| CAS No. | CATO-C4X-119126 |
| Molecular Formula | C26H17ClFN3O3 |
| Molecular Weight | 473.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Lapatinib Impurity 26 (CAS CATO-C4X-119126) is a certified pharmaceutical impurity reference standard with the molecular formula C26H17ClFN3O3 and a molecular weight of 473.88 g/mol.
Lapatinib Impurity 26 (C26H17ClFN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H17ClFN3O3 |
| Molecular Weight | 473.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Lapatinib Standards
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
- Lapatinib Impurity 14 (CAS 697299-82-4)
- Lapatinib Impurity 19 (CAS 320337-48-2)
- Lapatinib Impurity 6 (CAS 231278-25-4)
- Lapatinib Impurity 7 (CAS 320337-46-0)
- Lapatinib Impurity 11 (CAS 231278-83-4)
- Lapatinib Impurity 8 (CAS 202198-16-1)
Recommended Standards
- (2,3-Dibromopentafluoropropoxy)pentafluorobenzene (CAS 1309602-56-9)
- Afatinib Impurity 85 (CAS CATO-C4X-100685)
- (2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-(3,4-dimethoxyphenethyl)-1H-imidazol-5-yl)methanol (CAS 338422-54-1)
- 2-{2-[(3-methylphenyl)formamido]acetamido}ethyl 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate (CAS 338419-60-6)
- Cefcapene Impurity 97 (CAS CATO-C4X-182497)
- Ornidazole Impurity 7 (CAS 14419-11-5)
- Latanoprost EP Impurity C (CAS CATO-C4X-194117)
- 1-(4-(2-Aminophenyl)piperazin-1-yl)ethan-1-one (CAS 91646-45-6)
- 2-(5-Bromo-2,4-difluorophenoxy)-1,3-difluoro-5-(trifluoromethyl)benzene (CAS 2244085-48-9)
- 4-Fluoro-2-iodo-5-methylaniline (CAS 85233-15-4)
- N-(Naphthalen-2-yl)-3-oxobutanamide (CAS 42414-19-7)
- 1-(4-Morpholin-4-ylphenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 799013-49-3)
- (1H-indol-7-yl)(piperazin-1-yl)methanone hydrochloride (CAS 1574675-46-9)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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