Lapatinib Impurity 19 CAS 320337-48-2
| CAS No. | 320337-48-2 |
| Molecular Formula | C26H19ClFN3O3 |
| Molecular Weight | 475.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lapatinib Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lapatinib Impurity 19 (CAS 320337-48-2, C26H19ClFN3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Lapatinib Impurity 19 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 475.90 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C26H19ClFN3O3 |
| Molecular Weight | 475.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Lapatinib Standards
- Lapatinib Impurity 14 (CAS 697299-82-4)
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
- Lapatinib Impurity 6 (CAS 231278-25-4)
- Lapatinib Impurity 7 (CAS 320337-46-0)
- Lapatinib Impurity 11 (CAS 231278-83-4)
- Lapatinib Impurity 8 (CAS 202198-16-1)
Recommended Standards
- Methyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]-2,2-dibromo-acetate (CAS 318967-86-1)
- (4-(((4-Chlorobenzyl)sulfonyl)methyl)-4-hydroxypiperidin-1-yl)(3-(trifluoromethyl)phenyl)methanone (CAS 866019-54-7)
- (6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-N,8-diethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-6-methyl-1,9-dioxo-pyrazino[1,2:1,5]pyrrolo[2,3-d]pyridazine-4-carboxam (CAS 870005-19-9)
- 2-(2-(((4-Chlorophenyl)thio)methyl)-1H-benzo[d]imidazol-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide (CAS 339100-98-0)
- Riboflavin EP Impurity A (CAS 1088-56-8)
- Etrasimod impurity 19 (CAS CATO-C4X-321419)
- Cefazolin Impurity 63 (CAS CATO-C4X-157763)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-fluoro-5-nitropyridine (CAS 1807128-72-8)
- 7-Azaindole-6-carboxylic Acid (CAS 898746-35-5)
- 3-(Carboxymethyl)cyclobutane-1-carboxylic acid (CAS 2098129-74-7)
- 949588-40-3 Glycine, N-methyl-N-(((1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl)methyl)-, hydrochloride (1:1), rel- ORG 25935 cis-N-Methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid hydrochloride Org25935 ORG-25935 (CAS 949588-40-3)
- 1-Methylnaphthalene-3-carboxylic acid (CAS 5773-87-5)
- 4,4,5,5-Tetramethyl-2-[4-(pentafluorosulfanyl)phenyl]-1,3,2-dioxaborolane (CAS 1286278-34-9)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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