Tofacitinib Impurity 225 CAS 2026634-40-0
| CAS No. | 2026634-40-0 |
| Molecular Formula | C13H20N2 |
| Molecular Weight | 204.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 204.31 g/mol gives Tofacitinib Impurity 225 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Tofacitinib Impurity 225 (CAS 2026634-40-0, C13H20N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tofacitinib Impurity 225 (C13H20N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity 225 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H20N2 |
| Molecular Weight | 204.31 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 130 (CAS 2564-07-0)
- Tofacitinib Impurity 155 (CAS 2032-35-1)
- Tofacitinib Impurity 221 (CAS CATO-C4X-1079221)
- Tofacitinib Impurity 184 (CAS CATO-C4X-1079184)
- Tofacitinib Impurity 144 (CAS 2091669-67-7)
- Tofacitinib Impurity 126 (CAS 384338-23-2)
- Tofacitinib Impurity 208 (CAS 1638499-31-6)
- Tofacitinib Impurity 57 (CAS 477600-70-7)
Recommended Standards
- 898765-52-1 1-(2,3-Dimethylphenyl)-2,2-dimethylbutan-1-one DTXSID70642436 (CAS 898765-52-1)
- Sitafloxacin impurity 84 (CAS 1533823-99-2)
- 64UYT55005 7492-37-7 3-Benzyl-4-heptanone 4-Heptanone, 3-benzyl- (8CI) 4-Heptanone, 3-(phenylmethyl)- 3-(Phenylmethyl)heptan-4-one Benzyl dipropyl ketone 1-Benzyl dipropyl ketone 1-Benzyldipropyl ketone BRN 2262221 EINECS 231-317-4 FEMA No. 2146 4-Heptanone, 3-benzyl- Morellone 3-(Phenylmethyl)-4-heptanone UNII-64UYT55005 (CAS 7492-37-7)
- Propofol Impurity 38 (CAS CATO-C4X-147338)
- Ketorolac EP Impurity E (CAS 167105-80-8)
- Dalilesen Impurity 8 (CAS 1505484-72-9)
- Ketoprofen Impurity 22 (CAS 42872-29-7)
- 4-amino-1-benzyl-5-methylpyrrolidin-2-one hydrochloride (CAS 1803567-17-0)
- (1E,4E)-1,5-Bis[3,5-bis(methoxymethoxy)phenyl]-1,4-pentadiene-3-one (CAS 917813-62-8)
- 4,5-Dibromobenzene-1,2-diamine (CAS 49764-63-8)
- (E)-4-((4-(N-mesitylsulfamoyl)phenyl)amino)-4-oxobut-2-enoic acid (CAS 1164468-89-6)
- 5-(4-(Trimethylsilyl)phenyl)nicotinic acid (CAS 887973-37-7)
- Ethyl 4-(3-phenylpropyl)piperazine-1-carboxylate (CAS 59698-38-3)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com