Trametinib impurity 01 CAS 871701-87-0
| CAS No. | 871701-87-0 |
| Molecular Formula | C24H21FIN5O3 |
| Molecular Weight | 573.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Trametinib impurity 01 (C24H21FIN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 573.36 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Trametinib impurity 01 (CAS 871701-87-0) is a certified pharmaceutical impurity reference standard with the molecular formula C24H21FIN5O3 and a molecular weight of 573.36 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Trametinib impurity 01 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H21FIN5O3 |
| Molecular Weight | 573.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 5 |
Related Trametinib Standards
- Trametinib impurity 5 (CAS CATO-C4X-27825)
- Trametinib Impurity N5 (CAS 1620017-29-9)
- Trametinib impurity 4 (CAS CATO-C4X-27824)
- Trametinib Impurity 12 (CAS 1279693-89-8)
- Trametinib impurity 04 (CAS 871700-25-3)
- Trametinib Impurity N11 (CAS 871701-23-4)
- Trametinib (CAS 871700-17-3)
- Trametinib-13C-d3 (CAS 2712126-59-3)
Recommended Standards
- Delafloxacin Impurity 11 (CAS CATO-C4X-263711)
- Delafloxacin Impurity 10 (CAS CATO-C4X-263710)
- Tolvaptan Impurity 117 (CAS CATO-C4X-1955117)
- N-(3-isopropoxyphenyl)-2-(1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexyl)benzamide (CAS 680213-73-4)
- Sugammadex Impurity Org48301 (CAS 2412952-86-2)
- Semaglutide impurity 255 (CAS CATO-C4X-2226255)
- Lornoxicam Impurity 13 (CAS 2322849-92-1)
- 6-Methoxy-N-(3-(trifluoromethyl)benzyl)-2H-chromene-3-carboxamide (CAS 338760-52-4)
- 1-(3-Bromo-4-methylphenyl)-2,5-dimethyl-1H-pyrrole (CAS 736973-12-9)
- 2-(4-Oxothieno[3,2-d]pyrimidin-3(4H)-yl)acetonitrile (CAS 1223598-91-1)
- tert-Butyl (2-Methyl-1-oxopropan-2-yl)carbamate (CAS 109608-77-7)
- 1H-Benzo[d][1,2,3]triazole-1-carbonyl chloride (CAS 65095-13-8)
- (1R,2R,4R)-bicyclo[2.2.1]Heptan-2-amine (CAS 1821748-72-4)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com