Nilotinib Impurity 21 CAS CATO-C4X-125621
| CAS No. | CATO-C4X-125621 |
| Molecular Formula | C28H21ClF3N7O |
| Molecular Weight | 563.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nilotinib Impurity 21 (C28H21ClF3N7O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Nilotinib Impurity 21 (CAS CATO-C4X-125621) is a certified pharmaceutical impurity reference standard with the molecular formula C28H21ClF3N7O and a molecular weight of 563.97 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nilotinib Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H21ClF3N7O |
| Molecular Weight | 563.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib Impurity 41 (CAS CATO-C4X-125641)
- Nilotinib Impurity 49 (CAS CATO-C4X-125649)
- Nilotinib Impurity 48 (CAS CATO-C4X-125648)
- Nilotinib Impurity 46 (CAS 1807607-72-2)
- Nilotinib Impurity 35 (CAS CATO-C4X-125635)
- Nilotinib Impurity 39 (CAS 2925306-68-7)
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
Recommended Standards
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- 1,3,5-Tris(3,4-dichlorophenyl)-1,3,5-triazinane-2,4,6-trione (CAS 98329-02-3)
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- Piroxicam Impurity 23 Disodium Salt (CAS 88741-92-8 (free acid))
- Pimavanserin Impurity 4 (CAS 428819-12-9)
- 1-(2-Fluorophenyl)-3-phenyl-1h-pyrazole-5-carboxylic acid (CAS 618102-02-6)
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- (4-Cyclopropoxy-6-nitropyridin-3-yl)methanamine (CAS 1243482-07-6)
- methyl 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylate (CAS 1797234-37-7)
- 2-Ethoxy-3-(1-ethylpiperidin-2-yl)pyridine (CAS 1352500-48-1)
- 4-(Aminomethyl)-5-(difluoromethyl)-3-(trifluoromethyl)pyridin-2-amine (CAS 1805228-63-0)
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