Aprepitant Impurity 17 CAS 1333998-27-8
| CAS No. | 1333998-27-8 |
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Aprepitant Impurity 17.
As a process- or degradation-related impurity, Aprepitant Impurity 17 (CAS 1333998-27-8, C20H18F7NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Aprepitant Impurity 17 (C20H18F7NO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Aprepitant Impurity 17 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H18F7NO2 HCl |
| Molecular Weight | 473.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Moxifloxacin Impurity 20 (CAS 959347-97-8)
- Bisoprolol Impurity 81 (CAS 2775292-22-1)
- Carbasalate EP Impurity B (CAS 530-75-6)
- tert-Butyl N-[(3S,4S)-4-fluoropiperidin-3-yl]carbamate (CAS 1052713-48-0)
- N-(1,3-Benzodioxol-5-ylmethyl)-N-(4,6-dimethylpyrimidin-2-yl)guanidine (CAS 675142-99-1)
- N'-(4-bromo-2,6-dimethylphenyl)-N,N-dimethylformimidamide (CAS 114886-15-6)
- 2,3-Dichloro-4-(3-pyrrolinomethyl) benzophenone (CAS 898764-63-1)
- 1-(Benzylsulfonyl)-1,4-diazepane hydrochloride (CAS 1603766-70-6)
- 3-Methyl-6-(methylsulfonyl)benzo[d]thiazol-2(3H)-imine (CAS 1286699-99-7)
- Acetyl Tetrapeptide- 15 (CAS 928007-64-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com