Ezetimibe Impurity 44 CAS 204589-82-2
| CAS No. | 204589-82-2 |
| Molecular Formula | C25H22FNO4 |
| Molecular Weight | 419.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ezetimibe Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Ezetimibe Impurity 44 (CAS 204589-82-2), a pharmacopoeial impurity reference standard (molecular formula C25H22FNO4, MW 419.44 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ezetimibe Impurity 44 (C25H22FNO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H22FNO4 |
| Molecular Weight | 419.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 70 (CAS 937636-63-0)
- Ezetimibe-13C6 (CAS 438624-68-1)
- Ezetimibe Impurity 58 (CAS 1374250-08-4)
- Ezetimibe Impurity 39 (CAS 1093659-89-2)
- Ezetimibe-d4 (CAS 1093659-90-5)
- Ezetimibe Impurity 142 (CAS CATO-C4X-1098142)
- Ezetimibe Impurity 32 (CAS 1700622-08-7)
- Ezetimibe Impurity 13(Open Ring Impurity) (CAS 1197811-72-5)
Recommended Standards
- Pitavastatin Impurity 89 (CAS CATO-C4X-103789)
- Fmoc-4-fluoro-α-Me-Phe-OH · DCHA (CAS 1175838-03-5)
- Pitavastatin Impurity 88 (CAS 222306-15-2)
- 7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 127142-90-9)
- Dolutegravir Impurity 63 (CAS CATO-C4X-162063)
- Calcitriol Impurity 64 (CAS CATO-C4X-151064)
- Arbidol Impurity 23 (CAS CATO-C4X-112923)
- 1-methyl-1,4-dihydrocinnolin-4-one (CAS 1556-22-5)
- trans-2-(3-Fluoro-4-methylphenyl)cyclopentanol (CAS 933674-43-2)
- Pimelic acid anhydride (CAS 10521-07-0)
- 4-(2,4-Dimethylphenoxy)butan-1-ol (CAS 1153128-71-2)
- 5-Bromo-6-methyl-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid (CAS 90767-13-8)
- Tert-butyl 6-(1-hydroxyethyl)-3,4-dihydroquinoline-1(2H)-carboxylate (CAS 1779807-75-8)
- Semaglutide Impurity 148 (CAS CATO-C4X-2226148)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com