Ezetimibe Impurity 18 CAS 204589-80-0
| CAS No. | 204589-80-0 |
| Molecular Formula | C26H24FNO4 |
| Molecular Weight | 433.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Ezetimibe Impurity 18 (CAS 204589-80-0) is a certified pharmaceutical impurity reference standard with the molecular formula C26H24FNO4 and a molecular weight of 433.47 g/mol.
Structurally, Ezetimibe Impurity 18 (C26H24FNO4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 433.47 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Ezetimibe Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H24FNO4 |
| Molecular Weight | 433.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 117 (CAS 1013025-04-1)
- Ezetimibe Impurity 106 (CAS CATO-C4X-1098106)
- EzetimiBe Impurity 19 (CAS 1391053-63-6)
- Ezetimibe Impurity 88 (CAS 1618657-29-6)
- Ezetimibe Impurity 109 (CAS CATO-C4X-1098109)
- Ezetimibe Impurity 129 (CAS CATO-C4X-1098129)
- Ezetimibe Impurity 32 (CAS 1700622-08-7)
- Ezetimibe Impurity 142 (CAS CATO-C4X-1098142)
Recommended Standards
- 5-Oxo-Pitavastatin Methyl Ester (CAS 917752-45-5)
- N-((1S,2S)-2-((2,6-Dimethoxyphenyl)thio)-2,3-dihydro-1H-inden-1-yl)-1,1,1-trifluoromethanesulfonamide (CAS 2102520-58-9)
- (2S,4R)-Dibenzyl 4-((methylsulfonyl)oxy)pyrrolidine-1,2-dicarboxylate (CAS 1932292-95-9)
- N-(2,4-difluorophenyl)-2-(1,1-dioxidothiomorpholino)-3-(1H-indol-3-yl)propanamide (CAS 478040-46-9)
- Fluoropyrrolidine Impurity 3 (CAS CATO-C4X-31803)
- Ropinirole Impurity 27 (CAS 1027600-42-5 (free base))
- Ticagrelor Impurity 111 (CAS 1549834-66-3)
- 4-(p-Tolyl)butanoyl chloride (CAS 160699-02-5)
- 5,7-dichloro-6-methyl-1,8-naphthyridin-2-amine (CAS 131998-41-9)
- 2,5-Dimethoxybenzaldehyde (CAS 93-02-7)
- 2-(4-Aminophenyl)acetaldehyde (CAS 204838-36-8)
- 2,4-Diamino-6-methoxypyrimidine-5-carbonitrile (CAS 722457-66-1)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(dimethylamino)pyridin-2-yl)boronate (CAS 2223027-46-9)
- Atrial Natriuretic Peptide (ANP)(1-28) Alpha (Human, Ovine, Canine) (CAS 91917-63-4)
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