Tenofovir alafenamide impurity 74 CAS 2053424-88-5
| CAS No. | 2053424-88-5 |
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | 476.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Tenofovir alafenamide impurity 74 (CAS 2053424-88-5) is a certified pharmaceutical impurity reference standard with the molecular formula C21H29N6O5P and a molecular weight of 476.47 g/mol.
The molecular framework of Tenofovir alafenamide impurity 74 (C21H29N6O5P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Tenofovir alafenamide impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | 476.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 33 (CAS CATO-C4X-179733)
- Tenofovir alafenamide Impurity 42 (CAS 2053424-82-9)
- Tenofovir alafenamide Impurity 44 (CAS CATO-C4X-179744)
- Tenofovir alafenamide Impurity 45 (CAS CATO-C4X-179745)
- Tenofovir alafenamide Impurity 52 (CAS 383365-04-6)
- Tenofovir alafenamide (CAS 379270-37-8)
- Tenofovir alafenamide Impurity 62 (CAS CATO-C4X-179762)
- Tenofovir alafenamide impurity 75 (CAS 379270-36-7)
Recommended Standards
- Tenofovir alafenamide Impurity 8 (CAS CATO-C4X-17978)
- Tenofovir alafenamide impurity 86 (CAS CATO-C4X-179786)
- Tenofovir alafenamide impurity 87 (CAS CATO-C4X-179787)
- Tenofovir alafenamide Impurity 97 (CAS CATO-C4X-179797)
- Eldecalcitol Impurity 48 (CAS 197647-61-3)
- Atorvastatin Calcium EP Impurity F (CAS 887196-24-9)
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