Tenofovir alafenamide Impurity 45 CAS CATO-C4X-179745
| CAS No. | CATO-C4X-179745 |
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | 476.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Tenofovir alafenamide Impurity 45 (CAS CATO-C4X-179745, C21H29N6O5P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tenofovir alafenamide Impurity 45 (C21H29N6O5P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Tenofovir alafenamide Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | 476.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 33 (CAS CATO-C4X-179733)
- Tenofovir alafenamide Impurity 42 (CAS 2053424-82-9)
- Tenofovir alafenamide Impurity 44 (CAS CATO-C4X-179744)
- Tenofovir alafenamide Impurity 52 (CAS 383365-04-6)
- Tenofovir alafenamide (CAS 379270-37-8)
- Tenofovir alafenamide Impurity 62 (CAS CATO-C4X-179762)
- Tenofovir alafenamide impurity 74 (CAS 2053424-88-5)
- Tenofovir alafenamide impurity 75 (CAS 379270-36-7)
Recommended Standards
- Azacitidine Impurity 89 (CAS 69350-76-1)
- 485821-70-3 A827564 [2-methyl-6-oxidanyl-4,5-bis(phenylcarbonyloxy)oxan-3-yl] benzoate benzoic acid (4,5-dibenzoyloxy-6-hydroxy-2-methyl-3-oxanyl) ester (CAS 485821-70-3)
- N,N’,N”-Tris(3-aminoquinolino)phosphoric triamide (CAS 2097565-50-7)
- Tenofovir alafenamide Impurity 8 (CAS CATO-C4X-17978)
- Simvastatin EP Impurity I (CAS 79902-42-4)
- Alprostadil EP Impurity G (CAS 363-24-6)
- Ezetimibe Impurity 114 (CAS CATO-C4X-1098114)
- 2-Methyl-4-[3-(N-methylaminocarbonyl)phenyl]phenol (CAS 1261947-42-5)
- 4-((3,5-Dimethyl-1H-pyrazol-4-yl)methyl)phenol (CAS 75998-99-1)
- N1-((1,5-dimethyl-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine (CAS 1006348-94-2)
- 2-(Furan-2-yl)-2-(phenylsulfonyl)ethan-1-amine hydrochloride (CAS 1177327-36-4)
- 4-Chloro-5-fluoro-3-iodo-7H-pyrrolo[2,3-b]pyridine-6-carbaldehyde (CAS 1305324-96-2)
- (2-Chloro-5-(trifluoromethyl)phenyl)(phenyl)methanone (CAS 789-96-8)
- Peptide Impurity (CAS CATO-CPTD788810)
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