Bortezomib Impurity N54 HCl CAS 205393-21-1
| CAS No. | 205393-21-1 |
| Molecular Formula | C24H37BN2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Bortezomib Impurity N54 HCl (CAS 205393-21-1), a pharmacopoeial impurity reference standard (molecular formula C24H37BN2O3HCl, MW 448.84 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Bortezomib Impurity N54 HCl (C24H37BN2O3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Bortezomib Impurity N54 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H37BN2O3 HCl |
| Molecular Weight | 448.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Bortezomib Standards
- Bortezomib Impurity 77 (CAS 103435-88-7)
- Bortezomib Impurity 36 (CAS 1093959-75-1)
- Bortezomib Impurity 35 (CAS 1104011-35-9)
- Bortezomib Impurity 45 (CAS 110755-29-8)
- Bortezomib Impurity 6 (CAS 1132709-14-8)
- Bortezomib Impurity 7 (CAS 1132709-15-9)
- Bortezomib Impurity 5 (CAS 1132709-16-0)
- Bortezomib Impurity 2 (CAS 114457-94-2)
Recommended Standards
- Dacomitinib Impurity 17 (CAS CATO-C4X-208617)
- Bilastine Impurity 66 (CAS 2414420-72-5)
- Tegoprazan Impurity 15 (CAS CATO-C4X-229715)
- N-(3-(trifluoromethyl)phenyl)thieno[2,3-b]quinoline-2-carboxamide (CAS 439111-79-2)
- ethyl 2-amino-4-cyclopropyl-4-methoxybutanoate (CAS 1909309-91-6)
- 2-Bromo-1-fluoro-4-(methylsulfonyl)benzene (CAS 959961-65-0)
- 4-Bromo-3-(trifluoromethoxy)aniline (CAS 116369-25-6)
- 3-Bromo-8-iodoquinoline (CAS 1379316-32-1)
- (3-Nitro-1H-1,2,4-triazol-1-yl)methanol (CAS 74205-83-7)
- Peptide 434 (CAS CATO-CPTD788434)
Why CATO?
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