Sitagliptin Impurity 22 CAS 486460-23-5
| CAS No. | 486460-23-5 |
| Molecular Formula | C21H23F6N5O3 |
| Molecular Weight | 507.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Sitagliptin Impurity 22 (CAS 486460-23-5), a pharmacopoeial impurity reference standard (molecular formula C21H23F6N5O3, MW 507.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C21H23F6N5O3, Sitagliptin Impurity 22 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 507.43 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures Sitagliptin Impurity 22 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H23F6N5O3 |
| Molecular Weight | 507.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin Impurity 149 (CAS CATO-C4X-1144149)
- Sitagliptin Impurity 97 (CAS 1169707-29-2)
- Sitagliptin Impurity 87 (CAS CATO-C4X-114487)
- Sitagliptin Impurity 165 (CAS CATO-C4X-1144165)
- Sitagliptin Tablets EP Impurity FP-A (CAS 2088771-60-0)
- Sitagliptin Impurity 161 (CAS 1608491-98-0)
- Sitagliptin Impurity 104 (CAS CATO-C4X-1144104)
- Sitagliptin Impurity 128 (CAS CATO-C4X-1144128)
Recommended Standards
- 2-((N-(5-(Benzyloxy)-2,4-dichlorophenyl)-4-methylphenyl)sulfonamido)-N,N-dimethylacetamide (CAS 338967-32-1)
- Macitentan Impurity 21 (CAS CATO-C4X-117521)
- Chlorhexidine Impurity 6 (CAS 62247-48-7)
- 5,5'-(Acridine-2,7-diyl)diisophthalic acid (CAS 1527507-79-4)
- Upadacitinib Impurity 134 (CAS CATO-C4X-2405134)
- Cefdinir Impurity 85 (CAS CATO-C4X-121085)
- Cefixime Impurity 41 (CAS CATO-C4X-113941)
- 1-Cyclohexyl-3-(tert-butyldimethylsilyl)-2-propyn-1-ol (CAS 887586-33-6)
- 6-(4-Chlorophenyl)pyridazine-3-thiol (CAS 70391-14-9)
- 3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole (CAS 1346808-44-3)
- N-(2-Methoxyphenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide (CAS 312755-78-5)
- Fosfomycin Trometamol EP Impurity A (CAS 84954-80-3)
- 3-Bromo-4-ethylaniline (CAS 52121-36-5)
- Acetyl Hexapeptide-38 (CAS 1400634-44-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com