Halometasone Impurity 1 CAS 23961-24-2
| CAS No. | 23961-24-2 |
| Molecular Formula | C24H30Cl2F2O6 |
| Molecular Weight | 523.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Halometasone Impurity 1.
As a process- or degradation-related impurity, Halometasone Impurity 1 (CAS 23961-24-2, C24H30Cl2F2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Halometasone Impurity 1 (C24H30Cl2F2O6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 523.39 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H30Cl2F2O6 |
| Molecular Weight | 523.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F/Cl-containing |
Related Halometasone Standards
- Halometasone impurity 11 (CAS CATO-C4X-144611)
- Halometasone impurity 16 (CAS CATO-C4X-144616)
- Halometasone Impurity N3 (CAS 23961-22-0)
- Halometasone Impurity 2 (CAS CATO-C4X-14462)
- Halometasone Impurity 8 (CAS 28895-70-7)
- Halometasone impurity 12 (CAS CATO-C4X-144612)
- Halometasone impurity 10 (CAS CATO-C4X-144610)
- Halometasone impurity 13 (CAS CATO-C4X-144613)
Recommended Standards
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- Methyl 6-bromo-2-methyl-1H-indole-3-carboxylate (CAS 1313753-18-2)
- (R)-2-(1-(tert-Butoxycarbonyl)-3-oxopiperazin-2-yl)acetic acid (CAS 1240588-66-2)
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