Bictegravir Impurity 10(2R,5S,13aS) CAS CATO-C4X-218110
| CAS No. | CATO-C4X-218110 |
| Molecular Formula | C21H18F3N3O5 |
| Molecular Weight | 449.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Bictegravir Impurity 10(2R,5S,13aS) (CAS CATO-C4X-218110, C21H18F3N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Bictegravir Impurity 10(2R,5S,13aS) (C21H18F3N3O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18F3N3O5 |
| Molecular Weight | 449.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Bictegravir Standards
- Bictegravir (CAS 1611493-60-7)
- Bictegravir Impurity 8(2S,5R,13aS) (CAS CATO-C4X-21818)
- Bictegravir Impurity 9(2R,5R,13aR) (CAS CATO-C4X-21819)
- Bictegravir-15N, d2 (CAS CATO-C4X-21811)
- Bictegravir Related Compound C001/Dolutegravir Intermediate-1 (CAS 1335210-23-5)
- Bictegravir Impurity 2 (CAS CATO-C4X-21812)
- Bictegravir Related Compound 2 (CAS 1110772-05-8)
- Bictegravir impurity 11 (CAS CATO-C4X-218111)
Recommended Standards
- Sunitinib Impurity 79 (CAS CATO-C4X-133379)
- Sunitinib Impurity 77 (CAS CATO-C4X-133377)
- 3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R,2R)-2-(dimethylamino)cyclohexyl)amino)cyclobut-3-ene-1,2-dione (CAS 1211565-07-9)
- 6-{[(4-bromophenyl)sulfanyl]methyl}-2-{[(4-methoxyphenyl)methyl]sulfanyl}pyrimidin-4-ol (CAS 866143-65-9)
- Peramivir impurity 134 (CAS CATO-C4X-1833134)
- Isosulfan Blue impurity 9 (CAS CATO-C4X-30459)
- Sulfasalazine Impurity 2 (RRT 0.75) (CAS 139-56-0)
- 1-(2,3,6-Trihydroxyphenyl)ethanone (CAS 85918-30-5)
- 1-(2-(M-tolylamino)thiazol-5-yl)ethan-1-one (CAS 478078-69-2)
- 2-(Pyridin-2-yloxy)acetonitrile (CAS 218921-11-0)
- 4-(4-Methoxyphenyl)thiazole-2-carbaldehyde (CAS 383144-12-5)
- Ethyl 2-(4-acetyl-2-nitrophenyl)acetate (CAS 777062-26-7)
- 4-(Indolin-5-yl)morpholine (CAS 959238-58-5)
- Liraglutide (13-21) TFA Salt (CAS CATO-C4X-19928)
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