Acalabrutinib Impurity 24 CAS 2097352-14-0
| CAS No. | 2097352-14-0 |
| Molecular Formula | C14H14BrN5O |
| Molecular Weight | 348.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Acalabrutinib Impurity 24 (CAS 2097352-14-0), a pharmacopoeial impurity reference standard (molecular formula C14H14BrN5O, MW 348.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Acalabrutinib Impurity 24 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 348.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14BrN5O |
| Molecular Weight | 348.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 31 (CAS CATO-C4X-305531)
- Acalabrutinib Impurity 30 (CAS CATO-C4X-305530)
- Acalabrutinib Impurity 5 (CAS CATO-C4X-30555)
- Acalabrutinib Impurity 11 (CAS CATO-C4X-305511)
- Acalabrutinib Impurity 8 (CAS CATO-C4X-30558)
- Acalabrutinib Impurity 20 (CAS CATO-C4X-305520)
- Acalabrutinib Impurity 15 (CAS CATO-C4X-305515)
- Acalabrutinib Impurity 10 (CAS CATO-C4X-305510)
Recommended Standards
- Cis 4-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-nitrophenyl)-2-6-dimethylmorpholine (CAS 2016805-42-6)
- 2,3-Dichloro-N-(2-(6-oxopyridazin-1(6H)-yl)ethyl)benzenesulfonamide (CAS 1021219-41-9)
- 3-Bromo-1-(tetrahydro-2H-pyran-2-yl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole (CAS 395102-97-3)
- 2-(2-Bromo-4,5-dimethoxyphenyl)-1,3-thiazolidine-4-carboxylic acid (CAS 1101223-13-5)
- Indacaterol Impurity 51 (CAS CATO-C4X-150051)
- Apixaban Impurity 140 (CAS CATO-C4X-1088140)
- Oseltamivir EP Impurity C-d3 HCl (CAS CATO-C4X-172032)
- 1-Allyl-3-ethylbenzene (CAS 744221-41-8)
- (1-(3-Fluoro-4-methoxybenzyl)pyrrolidin-3-yl)methanol (CAS 1457410-78-4)
- 2-Chloro-8-fluoroquinolin-4-amine (CAS 1707359-89-4)
- 1-(2-(6-Bromopyridin-2-yl)morpholino)ethan-1-one (CAS 1316221-41-6)
- Acetylcysteine Impurity 22 (CAS 60333-15-5)
- 4-Chloro-2-iodo-5-(trifluoromethyl)pyridine (CAS 1227578-17-7)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com